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Fluorine in PDB 2q1l: Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Enzymatic activity of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
All present enzymatic activity of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors:
1.1.1.34;
1.1.1.34;
Protein crystallography data
The structure of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors, PDB code: 2q1l
was solved by
A.Pavlovsky,
J.A.Pfefferkorn,
M.S.Harris,
B.C.Finzel,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.49 / 2.05 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.732, 176.958, 76.735, 90.00, 118.83, 90.00 |
| R / Rfree (%) | 22.3 / 26.3 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
(pdb code 2q1l). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors, PDB code: 2q1l:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Fluorine where determined in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors, PDB code: 2q1l:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Fluorine binding site 1 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 1 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 2 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 2 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 3 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 3 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 4 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 4 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 5 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 5 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 6 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 6 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 7 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 7 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 8 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 8 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Reference:
J.A.Pfefferkorn,
Y.Song,
K.L.Sun,
S.R.Miller,
B.K.Trivedi,
C.Choi,
R.J.Sorenson,
L.D.Bratton,
P.C.Unangst,
S.D.Larsen,
T.J.Poel,
X.M.Cheng,
C.Lee,
N.Erasga,
B.Auerbach,
V.Askew,
L.Dillon,
J.C.Hanselman,
Z.Lin,
G.Lu,
A.Robertson,
K.Olsen,
T.Mertz,
C.Sekerke,
A.Pavlovsky,
M.S.Harris,
G.Bainbridge,
N.Caspers,
H.Chen,
M.Eberstadt.
Design and Synthesis of Hepatoselective, Pyrrole-Based Hmg-Coa Reductase Inhibitors. Bioorg.Med.Chem.Lett. V. 17 4538 2007.
ISSN: ISSN 0960-894X
PubMed: 17574412
DOI: 10.1016/J.BMCL.2007.05.096
Page generated: Wed Jul 31 15:40:00 2024
ISSN: ISSN 0960-894X
PubMed: 17574412
DOI: 10.1016/J.BMCL.2007.05.096
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