Fluorine »
PDB 2pdl-2q94 »
2q1l »
Fluorine in PDB 2q1l: Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Enzymatic activity of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
All present enzymatic activity of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors:
1.1.1.34;
1.1.1.34;
Protein crystallography data
The structure of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors, PDB code: 2q1l
was solved by
A.Pavlovsky,
J.A.Pfefferkorn,
M.S.Harris,
B.C.Finzel,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.49 / 2.05 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.732, 176.958, 76.735, 90.00, 118.83, 90.00 |
| R / Rfree (%) | 22.3 / 26.3 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
(pdb code 2q1l). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors, PDB code: 2q1l:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Fluorine where determined in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors, PDB code: 2q1l:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Fluorine binding site 1 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 1 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 2 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 2 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 3 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 3 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 4 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 4 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 5 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 5 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 6 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 6 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 7 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 7 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 8 out of 8 in 2q1l
Go back to
Fluorine Binding Sites List in 2q1l
Fluorine binding site 8 out
of 8 in the Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Design and Synthesis of Pyrrole-Based, Hepatoselective Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Reference:
J.A.Pfefferkorn,
Y.Song,
K.L.Sun,
S.R.Miller,
B.K.Trivedi,
C.Choi,
R.J.Sorenson,
L.D.Bratton,
P.C.Unangst,
S.D.Larsen,
T.J.Poel,
X.M.Cheng,
C.Lee,
N.Erasga,
B.Auerbach,
V.Askew,
L.Dillon,
J.C.Hanselman,
Z.Lin,
G.Lu,
A.Robertson,
K.Olsen,
T.Mertz,
C.Sekerke,
A.Pavlovsky,
M.S.Harris,
G.Bainbridge,
N.Caspers,
H.Chen,
M.Eberstadt.
Design and Synthesis of Hepatoselective, Pyrrole-Based Hmg-Coa Reductase Inhibitors. Bioorg.Med.Chem.Lett. V. 17 4538 2007.
ISSN: ISSN 0960-894X
PubMed: 17574412
DOI: 10.1016/J.BMCL.2007.05.096
Page generated: Wed Jul 31 15:40:00 2024
ISSN: ISSN 0960-894X
PubMed: 17574412
DOI: 10.1016/J.BMCL.2007.05.096
Last articles
Zn in 9JYWZn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
