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PDB 2pdl-2q94 »
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Fluorine in PDB 2q8g: Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545
Enzymatic activity of Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545
All present enzymatic activity of Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545:
2.7.11.2;
2.7.11.2;
Protein crystallography data
The structure of Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545, PDB code: 2q8g
was solved by
M.Kato,
J.Li,
J.L.Chuang,
D.T.Chuang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 1.90 |
| Space group | P 41 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 96.979, 96.979, 111.352, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 21.2 / 24.9 |
Other elements in 2q8g:
The structure of Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545 also contains other interesting chemical elements:
| Potassium | (K) | 1 atom |
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545
(pdb code 2q8g). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545, PDB code: 2q8g:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545, PDB code: 2q8g:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 2q8g
Go back to
Fluorine Binding Sites List in 2q8g
Fluorine binding site 1 out
of 3 in the Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545 within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 2q8g
Go back to
Fluorine Binding Sites List in 2q8g
Fluorine binding site 2 out
of 3 in the Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545 within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 2q8g
Go back to
Fluorine Binding Sites List in 2q8g
Fluorine binding site 3 out
of 3 in the Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Structure of Pyruvate Dehydrogenase Kinase Isoform 1 in Complex with Glucose-Lowering Drug AZD7545 within 5.0Å range:
|
Reference:
M.Kato,
J.Li,
J.L.Chuang,
D.T.Chuang.
Distinct Structural Mechanisms For Inhibition of Pyruvate Dehydrogenase Kinase Isoforms By AZD7545, Dichloroacetate, and Radicicol. Structure V. 15 992 2007.
ISSN: ISSN 0969-2126
PubMed: 17683942
DOI: 10.1016/J.STR.2007.07.001
Page generated: Sun Dec 13 11:39:21 2020
ISSN: ISSN 0969-2126
PubMed: 17683942
DOI: 10.1016/J.STR.2007.07.001
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