Fluorine in PDB 2qs4: Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution

The structure of Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution, PDB code: 2qs4 was solved by G.M.Alushin, D.E.Jane, M.L.Mayer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.64 / 1.58
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	89.241, 89.241, 330.365, 90.00, 90.00, 120.00
R / Rfree (%)	15.8 / 19.9

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution (pdb code 2qs4). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution, PDB code: 2qs4:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:F260 b:21.8 occ:0.60 F2 A:LY5260 0.0 21.8 0.6 C15 A:LY5260 1.3 16.0 0.6 OG A:SER173 1.8 13.9 0.3 F1 A:LY5260 2.0 17.9 0.6 C16 A:LY5260 2.4 13.4 0.6 C14 A:LY5260 2.4 15.4 0.6 O A:HOH313 2.8 35.2 1.0 CB A:SER173 2.9 11.1 0.3 F2 A:LY5260 3.0 14.8 0.4 CB A:SER173 3.0 10.1 0.3 C12 A:LY5260 3.0 10.4 0.6 CB A:SER173 3.1 10.5 0.3 C14 A:LY5260 3.1 10.3 0.4 C12 A:LY5260 3.2 10.6 0.4 C16 A:LY5260 3.2 12.8 0.4 N2 A:LY5260 3.3 8.9 0.6 C15 A:LY5260 3.3 13.6 0.4 CE A:MET189 3.4 15.9 0.5 SD A:MET189 3.4 11.5 0.5 O A:HOH321 3.5 22.6 1.0 OG A:SER173 3.6 7.8 0.3 OG A:SER173 3.6 10.9 0.3 N2 A:LY5260 3.7 10.3 0.4 C11 A:LY5260 4.0 10.3 0.4 CG A:MET189 4.0 7.9 0.5 C11 A:LY5260 4.1 9.1 0.6 CA A:SER173 4.1 10.3 0.3 CA A:SER173 4.2 9.5 0.3 CA A:SER173 4.2 10.5 0.3 OG A:SER193 4.3 8.1 1.0 O A:HOH274 4.4 20.5 1.0 CB A:SER193 4.5 7.5 1.0 C13 A:LY5260 4.5 11.6 0.4 O A:HOH445 4.5 32.5 1.0 C13 A:LY5260 4.5 12.7 0.6 CG A:MET189 4.6 10.4 0.5 F1 A:LY5260 4.6 18.7 0.4 N A:SER173 4.6 10.3 0.3 N A:SER173 4.6 9.8 0.3 N A:SER173 4.6 10.1 0.3 SD A:MET189 4.7 13.8 0.5 CG2 A:VAL137 4.7 6.9 1.0 O3 A:LY5260 4.8 9.9 0.4 C7 A:LY5260 4.9 10.3 1.0

Fluorine binding site 2 out of 12 in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:F260 b:14.8 occ:0.40 F2 A:LY5260 0.0 14.8 0.4 F1 A:LY5260 1.1 17.9 0.6 C15 A:LY5260 1.3 13.6 0.4 C15 A:LY5260 1.9 16.0 0.6 F1 A:LY5260 2.0 18.7 0.4 C14 A:LY5260 2.3 10.3 0.4 C16 A:LY5260 2.3 12.8 0.4 C16 A:LY5260 2.5 13.4 0.6 C14 A:LY5260 2.6 15.4 0.6 O A:HOH274 2.9 20.5 1.0 F2 A:LY5260 3.0 21.8 0.6 OG A:SER173 3.1 13.9 0.3 C12 A:LY5260 3.4 10.6 0.4 N2 A:LY5260 3.4 8.9 0.6 N2 A:LY5260 3.5 10.3 0.4 C12 A:LY5260 3.7 10.4 0.6 CG1 A:VAL137 3.7 10.8 1.0 O A:HOH517 3.9 0.0 1.0 O A:HOH445 4.0 32.5 1.0 CB A:VAL137 4.0 7.3 1.0 CG2 A:VAL137 4.0 6.9 1.0 O A:HOH354 4.1 23.0 1.0 O A:HOH313 4.1 35.2 1.0 N A:SER173 4.3 10.1 0.3 N A:SER173 4.3 9.8 0.3 N A:SER173 4.3 10.3 0.3 CB A:SER173 4.3 11.1 0.3 CB A:SER173 4.4 10.5 0.3 CB A:SER173 4.4 10.1 0.3 O A:HOH345 4.5 23.5 1.0 O A:HOH482 4.5 31.5 1.0 O A:HOH367 4.6 27.5 1.0 C13 A:LY5260 4.6 11.6 0.4 C11 A:LY5260 4.6 10.3 0.4 OG A:SER173 4.6 7.8 0.3 CA A:SER173 4.8 10.3 0.3 C11 A:LY5260 4.8 9.1 0.6 C13 A:LY5260 4.8 12.7 0.6 CA A:SER173 4.9 9.5 0.3 CA A:SER173 4.9 10.5 0.3 O4 A:LY5260 5.0 15.4 0.4

Fluorine binding site 3 out of 12 in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:F260 b:17.9 occ:0.60 F1 A:LY5260 0.0 17.9 0.6 F2 A:LY5260 1.1 14.8 0.4 C15 A:LY5260 1.3 16.0 0.6 C15 A:LY5260 2.0 13.6 0.4 F2 A:LY5260 2.0 21.8 0.6 OG A:SER173 2.1 13.9 0.3 C16 A:LY5260 2.3 13.4 0.6 C14 A:LY5260 2.4 15.4 0.6 C14 A:LY5260 2.5 10.3 0.4 C16 A:LY5260 2.6 12.8 0.4 O A:HOH274 2.9 20.5 1.0 F1 A:LY5260 3.0 18.7 0.4 O A:HOH313 3.3 35.2 1.0 CB A:SER173 3.3 11.1 0.3 C12 A:LY5260 3.4 10.6 0.4 CB A:SER173 3.4 10.5 0.3 CB A:SER173 3.4 10.1 0.3 N2 A:LY5260 3.4 8.9 0.6 C12 A:LY5260 3.5 10.4 0.6 N2 A:LY5260 3.7 10.3 0.4 OG A:SER173 3.8 7.8 0.3 N A:SER173 3.8 10.1 0.3 N A:SER173 3.8 10.3 0.3 N A:SER173 3.8 9.8 0.3 CG2 A:VAL137 3.9 6.9 1.0 O A:HOH445 3.9 32.5 1.0 CA A:SER173 4.0 10.3 0.3 CA A:SER173 4.1 9.5 0.3 CA A:SER173 4.1 10.5 0.3 CG1 A:VAL137 4.2 10.8 1.0 CB A:VAL137 4.3 7.3 1.0 OG A:SER173 4.5 10.9 0.3 C11 A:LY5260 4.6 10.3 0.4 O A:HOH517 4.6 0.0 1.0 C13 A:LY5260 4.7 11.6 0.4 C11 A:LY5260 4.7 9.1 0.6 C A:ASN172 4.7 9.4 1.0 O A:HOH354 4.8 23.0 1.0 C13 A:LY5260 4.8 12.7 0.6 O A:HOH345 4.9 23.5 1.0 CE A:MET189 5.0 15.9 0.5

Fluorine binding site 4 out of 12 in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:F260 b:18.7 occ:0.40 F1 A:LY5260 0.0 18.7 0.4 C15 A:LY5260 1.3 13.6 0.4 F2 A:LY5260 2.0 14.8 0.4 C14 A:LY5260 2.4 10.3 0.4 C16 A:LY5260 2.4 12.8 0.4 O A:HOH354 2.4 23.0 1.0 O A:HOH517 2.7 0.0 1.0 F1 A:LY5260 3.0 17.9 0.6 N2 A:LY5260 3.2 10.3 0.4 C16 A:LY5260 3.2 13.4 0.6 C14 A:LY5260 3.2 15.4 0.6 C15 A:LY5260 3.3 16.0 0.6 C12 A:LY5260 3.4 10.6 0.4 O A:HOH367 3.5 27.5 1.0 N2 A:LY5260 3.5 8.9 0.6 CA A:GLY140 3.7 11.8 1.0 CG1 A:VAL137 3.7 10.8 1.0 C12 A:LY5260 3.9 10.4 0.6 O4 A:LY5260 4.1 15.4 0.4 CB A:VAL137 4.2 7.3 1.0 O4 A:LY5260 4.2 15.6 0.6 C13 A:LY5260 4.2 11.6 0.4 O A:HOH345 4.4 23.5 1.0 O A:HOH274 4.5 20.5 1.0 C13 A:LY5260 4.5 12.7 0.6 N A:GLY140 4.6 11.2 1.0 F2 A:LY5260 4.6 21.8 0.6 C11 A:LY5260 4.6 10.3 0.4 O A:HOH482 4.6 31.5 1.0 N A:SER141 4.7 9.9 0.5 N A:SER141 4.8 10.2 0.5 C A:GLY140 4.8 10.6 1.0 CG2 A:VAL137 4.8 6.9 1.0 C11 A:LY5260 4.8 9.1 0.6 O A:HOH269 4.9 11.8 1.0 OG A:SER173 5.0 13.9 0.3

Fluorine binding site 5 out of 12 in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:F259 b:21.2 occ:0.50 F2 B:LY5259 0.0 21.2 0.5 F1 B:LY5259 0.8 23.7 0.5 C15 B:LY5259 1.1 21.9 0.5 C15 B:LY5259 1.3 21.7 0.5 F2 B:LY5259 1.4 22.9 0.5 F1 B:LY5259 2.2 24.6 0.5 C14 B:LY5259 2.3 21.4 0.5 C16 B:LY5259 2.3 21.5 0.5 C14 B:LY5259 2.4 20.7 0.5 C16 B:LY5259 2.4 20.4 0.5 O B:HOH322 2.9 26.4 1.0 OG B:SER173 3.0 17.4 0.5 N2 B:LY5259 3.4 18.5 0.5 C12 B:LY5259 3.5 19.6 0.5 C12 B:LY5259 3.5 20.6 0.5 N2 B:LY5259 3.5 17.9 0.5 CG1 B:VAL137 3.5 12.4 1.0 CG2 B:VAL137 3.7 11.7 1.0 O B:HOH450 3.8 49.0 1.0 CB B:VAL137 3.8 13.3 1.0 N B:SER173 4.1 14.8 0.5 CB B:SER173 4.1 17.1 0.5 N B:SER173 4.1 14.8 0.5 CB B:SER173 4.3 17.1 0.5 O B:HOH357 4.5 30.8 1.0 OG B:SER173 4.6 17.4 0.5 C11 B:LY5259 4.6 16.8 0.5 CA B:SER173 4.7 15.5 0.5 C13 B:LY5259 4.7 18.1 0.5 CA B:SER173 4.7 15.5 0.5 C13 B:LY5259 4.7 20.7 0.5 C11 B:LY5259 4.8 16.3 0.5 C B:ASN172 4.8 14.3 1.0 O4 B:LY5259 4.9 17.8 0.5 CA B:ASN172 4.9 14.6 1.0 O B:HOH500 4.9 32.3 1.0

Fluorine binding site 6 out of 12 in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:F259 b:22.9 occ:0.50 F2 B:LY5259 0.0 22.9 0.5 C15 B:LY5259 1.3 21.9 0.5 F2 B:LY5259 1.4 21.2 0.5 OG B:SER173 1.7 17.4 0.5 F1 B:LY5259 2.2 23.7 0.5 C15 B:LY5259 2.2 21.7 0.5 C16 B:LY5259 2.3 20.4 0.5 C14 B:LY5259 2.4 21.4 0.5 C14 B:LY5259 2.4 20.7 0.5 C16 B:LY5259 2.9 21.5 0.5 CB B:SER173 2.9 17.1 0.5 O B:HOH322 2.9 26.4 1.0 CB B:SER173 3.0 17.1 0.5 C12 B:LY5259 3.3 20.6 0.5 F1 B:LY5259 3.3 24.6 0.5 C12 B:LY5259 3.4 19.6 0.5 N2 B:LY5259 3.4 18.5 0.5 OG B:SER173 3.5 17.4 0.5 N B:SER173 3.6 14.8 0.5 N B:SER173 3.6 14.8 0.5 CG2 B:VAL137 3.6 11.7 1.0 CA B:SER173 3.7 15.5 0.5 CA B:SER173 3.7 15.5 0.5 N2 B:LY5259 3.7 17.9 0.5 CB B:VAL137 4.2 13.3 1.0 CG1 B:VAL137 4.3 12.4 1.0 C11 B:LY5259 4.5 16.8 0.5 C B:ASN172 4.5 14.3 1.0 C11 B:LY5259 4.6 16.3 0.5 CE B:MET189 4.7 10.8 1.0 C13 B:LY5259 4.7 20.7 0.5 C13 B:LY5259 4.7 18.1 0.5 O B:HOH450 4.8 49.0 1.0 O B:HOH435 4.8 27.3 1.0 CA B:ASN172 5.0 14.6 1.0 O B:HOH357 5.0 30.8 1.0

Fluorine binding site 7 out of 12 in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:F259 b:24.6 occ:0.50 F1 B:LY5259 0.0 24.6 0.5 C15 B:LY5259 1.3 21.7 0.5 F1 B:LY5259 1.5 23.7 0.5 F2 B:LY5259 2.2 21.2 0.5 C15 B:LY5259 2.3 21.9 0.5 C14 B:LY5259 2.3 20.7 0.5 C14 B:LY5259 2.3 21.4 0.5 C16 B:LY5259 2.4 21.5 0.5 N2 B:LY5259 3.0 17.9 0.5 C16 B:LY5259 3.2 20.4 0.5 C12 B:LY5259 3.2 19.6 0.5 O B:HOH500 3.3 32.3 1.0 N2 B:LY5259 3.3 18.5 0.5 F2 B:LY5259 3.3 22.9 0.5 C12 B:LY5259 3.3 20.6 0.5 CG1 B:VAL137 3.4 12.4 1.0 CA B:GLY140 3.4 14.6 1.0 O4 B:LY5259 3.5 17.8 0.5 CB B:VAL137 3.7 13.3 1.0 O4 B:LY5259 3.7 21.4 0.5 C13 B:LY5259 3.8 18.1 0.5 C13 B:LY5259 4.0 20.7 0.5 O B:HOH455 4.0 43.9 1.0 O B:HOH274 4.1 16.0 1.0 CG2 B:VAL137 4.3 11.7 1.0 N B:GLY140 4.4 16.3 1.0 N B:SER141 4.4 14.0 0.5 N B:SER141 4.4 13.8 0.5 C B:GLY140 4.4 14.2 1.0 C11 B:LY5259 4.5 16.8 0.5 O B:HOH450 4.6 49.0 1.0 C11 B:LY5259 4.7 16.3 0.5 O B:VAL137 4.7 12.9 1.0 OG B:SER173 4.9 17.4 0.5 O B:HOH322 4.9 26.4 1.0 CA B:VAL137 4.9 12.9 1.0 O B:HOH261 5.0 15.6 1.0

Fluorine binding site 8 out of 12 in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:F259 b:23.7 occ:0.50 F1 B:LY5259 0.0 23.7 0.5 F2 B:LY5259 0.8 21.2 0.5 C15 B:LY5259 1.0 21.7 0.5 C15 B:LY5259 1.3 21.9 0.5 F1 B:LY5259 1.5 24.6 0.5 C16 B:LY5259 1.9 21.5 0.5 F2 B:LY5259 2.2 22.9 0.5 C16 B:LY5259 2.3 20.4 0.5 C14 B:LY5259 2.4 21.4 0.5 C14 B:LY5259 2.4 20.7 0.5 N2 B:LY5259 3.1 18.5 0.5 N2 B:LY5259 3.1 17.9 0.5 C12 B:LY5259 3.4 19.6 0.5 C12 B:LY5259 3.4 20.6 0.5 O B:HOH322 3.5 26.4 1.0 CG1 B:VAL137 3.6 12.4 1.0 O B:HOH450 3.7 49.0 1.0 OG B:SER173 3.8 17.4 0.5 CB B:VAL137 4.0 13.3 1.0 O B:HOH500 4.2 32.3 1.0 CG2 B:VAL137 4.2 11.7 1.0 O B:HOH357 4.2 30.8 1.0 C11 B:LY5259 4.4 16.8 0.5 C13 B:LY5259 4.5 18.1 0.5 O4 B:LY5259 4.5 17.8 0.5 C11 B:LY5259 4.5 16.3 0.5 C13 B:LY5259 4.6 20.7 0.5 O B:HOH455 4.6 43.9 1.0 O4 B:LY5259 4.7 21.4 0.5 CA B:GLY140 4.9 14.6 1.0 N B:SER173 4.9 14.8 0.5 N B:SER173 4.9 14.8 0.5 CB B:SER173 4.9 17.1 0.5 C7 B:LY5259 5.0 13.2 1.0

Fluorine binding site 9 out of 12 in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:F259 b:32.6 occ:1.00 F2 C:LY5259 0.0 32.6 1.0 C15 C:LY5259 1.3 29.6 1.0 F1 C:LY5259 2.1 33.4 1.0 C16 C:LY5259 2.3 27.4 1.0 C14 C:LY5259 2.3 25.5 1.0 OG C:SER173 2.6 19.4 0.5 O C:HOH305 2.7 26.6 1.0 C12 C:LY5259 3.4 23.1 1.0 N2 C:LY5259 3.4 23.1 1.0 CG2 C:VAL137 3.7 14.2 1.0 CB C:SER173 3.8 16.9 0.5 CG1 C:VAL137 3.8 14.5 1.0 N C:SER173 3.9 15.7 0.5 CB C:SER173 3.9 16.3 0.5 N C:SER173 3.9 15.9 0.5 CB C:VAL137 4.0 13.2 1.0 CA C:SER173 4.3 16.1 0.5 CA C:SER173 4.4 15.5 0.5 OG C:SER173 4.4 17.1 0.5 O C:HOH392 4.6 34.9 1.0 C11 C:LY5259 4.6 17.7 1.0 C13 C:LY5259 4.7 22.8 1.0 C C:ASN172 4.7 15.5 1.0 CA C:ASN172 4.9 15.2 1.0

Fluorine binding site 10 out of 12 in the Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Crystal Structure of the GLUR5 Ligand Binding Core Dimer in Complex with LY466195 at 1.58 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:F259 b:33.4 occ:1.00 F1 C:LY5259 0.0 33.4 1.0 C15 C:LY5259 1.3 29.6 1.0 F2 C:LY5259 2.1 32.6 1.0 C14 C:LY5259 2.3 25.5 1.0 C16 C:LY5259 2.4 27.4 1.0 N2 C:LY5259 3.1 23.1 1.0 C12 C:LY5259 3.3 23.1 1.0 O C:HOH366 3.4 36.4 1.0 CG1 C:VAL137 3.5 14.5 1.0 CB C:VAL137 3.8 13.2 1.0 O4 C:LY5259 3.8 25.4 1.0 CA C:GLY140 3.9 15.4 1.0 C13 C:LY5259 4.0 22.8 1.0 O C:HOH551 4.1 42.4 1.0 CG2 C:VAL137 4.3 14.2 1.0 O C:HOH305 4.3 26.6 1.0 O C:HOH262 4.5 19.2 1.0 C11 C:LY5259 4.5 17.7 1.0 OG C:SER173 4.5 19.4 0.5 O C:HOH392 4.6 34.9 1.0 N C:GLY140 4.8 15.7 1.0 N C:SER141 4.8 15.2 0.5 N C:SER141 4.8 14.9 0.5 C C:GLY140 4.9 14.8 1.0

G.M.Alushin, D.Jane, M.L.Mayer. Binding Site and Ligand Flexibility Revealed By High Resolution Crystal Structures of GLUK1 Competitive Antagonists. Neuropharmacology V. 60 126 2011.
ISSN: ISSN 0028-3908
PubMed: 20558186
DOI: 10.1016/J.NEUROPHARM.2010.06.002