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Fluorine in PDB 2v7w: X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin
Enzymatic activity of X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin
All present enzymatic activity of X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin:
2.5.1.63;
2.5.1.63;
Protein crystallography data
The structure of X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin, PDB code: 2v7w
was solved by
X.Zhu,
D.O'hagan,
J.H.Naismith,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 53.38 / 1.90 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 75.854, 129.256, 184.485, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18.7 / 22.1 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin
(pdb code 2v7w). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin, PDB code: 2v7w:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin, PDB code: 2v7w:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 2v7w
Go back to
Fluorine Binding Sites List in 2v7w
Fluorine binding site 1 out
of 3 in the X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 2v7w
Go back to
Fluorine Binding Sites List in 2v7w
Fluorine binding site 2 out
of 3 in the X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 2v7w
Go back to
Fluorine Binding Sites List in 2v7w
Fluorine binding site 3 out
of 3 in the X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase S158G Mutant Complexed with 5'-Fluorodeoxyadenosin within 5.0Å range:
|
Reference:
X.Zhu,
D.A.Robinson,
A.R.Mcewan,
D.O'hagan,
J.H.Naismith.
Mechanism of Enzymatic Fluorination in Streptomyces Cattleya. J. Am. Chem. Soc. V. 129 14597 2007.
ISSN: ESSN 1520-5126
PubMed: 17985882
DOI: 10.1021/JA0731569
Page generated: Wed Jul 31 16:03:25 2024
ISSN: ESSN 1520-5126
PubMed: 17985882
DOI: 10.1021/JA0731569
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