Fluorine in PDB 2v8y: Crystallographic and Mass Spectrometric Characterisation of EIF4E with N7-Cap Derivatives

The structure of Crystallographic and Mass Spectrometric Characterisation of EIF4E with N7-Cap Derivatives, PDB code: 2v8y was solved by C.J.Brown, I.Mcnae, P.M.Fischer, M.D.Walkinshaw, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.30 / 2.10
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	38.438, 100.731, 135.334, 90.00, 90.00, 90.00
R / Rfree (%)	20.3 / 25

The binding sites of Fluorine atom in the Crystallographic and Mass Spectrometric Characterisation of EIF4E with N7-Cap Derivatives (pdb code 2v8y). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystallographic and Mass Spectrometric Characterisation of EIF4E with N7-Cap Derivatives, PDB code: 2v8y:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Crystallographic and Mass Spectrometric Characterisation of EIF4E with N7-Cap Derivatives


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystallographic and Mass Spectrometric Characterisation of EIF4E with N7-Cap Derivatives within 5.0Å range: probe atom residue distance (Å) B Occ A:F1218 b:26.8 occ:1.00 FAH A:MGV1218 0.0 26.8 1.0 CAU A:MGV1218 1.3 25.2 1.0 CAJ A:MGV1218 2.3 25.7 1.0 CAI A:MGV1218 2.4 26.2 1.0 O A:HOH2134 2.8 21.5 1.0 NH1 A:ARG112 3.1 27.2 1.0 CZ A:ARG112 3.1 25.1 1.0 CG2 A:THR203 3.2 33.3 1.0 NE A:ARG112 3.3 24.4 1.0 CD A:ARG112 3.5 21.8 1.0 ND1 A:HIS200 3.5 18.2 1.0 CB A:THR203 3.6 34.0 1.0 CAL A:MGV1218 3.6 24.0 1.0 CAK A:MGV1218 3.6 24.6 1.0 OG1 A:THR203 3.7 32.7 1.0 NH2 A:ARG112 3.8 24.0 1.0 CAV A:MGV1218 4.1 25.9 1.0 CE1 A:HIS200 4.1 17.6 1.0 O A:HOH2133 4.2 43.0 1.0 CE3 A:TRP102 4.6 23.8 1.0 CG A:HIS200 4.7 20.6 1.0 CZ3 A:TRP102 4.8 22.8 1.0 CG A:ARG112 4.9 16.8 1.0 O A:HOH2146 4.9 25.1 1.0 CA A:HIS200 4.9 23.0 1.0

Fluorine binding site 2 out of 2 in the Crystallographic and Mass Spectrometric Characterisation of EIF4E with N7-Cap Derivatives


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystallographic and Mass Spectrometric Characterisation of EIF4E with N7-Cap Derivatives within 5.0Å range: probe atom residue distance (Å) B Occ E:F1218 b:42.9 occ:1.00 FAH E:MGV1218 0.0 42.9 1.0 CAU E:MGV1218 1.3 40.5 1.0 CAJ E:MGV1218 2.4 40.1 1.0 CAI E:MGV1218 2.4 42.5 1.0 O E:HOH2123 3.4 29.8 1.0 CD2 E:HIS200 3.5 23.8 1.0 OD2 E:ASP202 3.6 48.4 1.0 CAL E:MGV1218 3.6 39.7 1.0 CA E:HIS200 3.6 32.4 1.0 CAK E:MGV1218 3.6 42.0 1.0 O E:HIS200 3.8 34.9 1.0 CB E:HIS200 3.9 31.3 1.0 CG E:HIS200 4.0 28.9 1.0 CAV E:MGV1218 4.1 40.4 1.0 C E:HIS200 4.2 34.9 1.0 CE3 E:TRP102 4.2 37.3 1.0 CG E:ASP202 4.2 48.3 1.0 OD1 E:ASP202 4.3 50.0 1.0 NE2 E:HIS200 4.7 26.6 1.0 O E:THR203 4.7 49.9 1.0 CB E:TRP102 4.7 29.4 1.0 N E:HIS200 4.8 31.8 1.0 NE E:ARG112 4.9 29.7 1.0 CZ E:ARG112 4.9 29.3 1.0 CD2 E:TRP102 4.9 34.8 1.0 CZ3 E:TRP102 4.9 36.5 1.0 O E:SER199 4.9 31.9 1.0

C.J.Brown, I.Mcnae, P.M.Fischer, M.D.Walkinshaw. Crystallographic and Mass Spectrometric Characterisation of EIF4E with N(7)-Alkylated Cap Derivatives. J.Mol.Biol. V. 372 7 2007.
ISSN: ISSN 0022-2836
PubMed: 17631896
DOI: 10.1016/J.JMB.2007.06.033