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Fluorine in PDB 2vex: Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor
Enzymatic activity of Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor
All present enzymatic activity of Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor:
3.1.3.48;
3.1.3.48;
Protein crystallography data
The structure of Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor, PDB code: 2vex
was solved by
B.Douty,
B.Wayland,
P.J.Ala,
M.J.Bower,
J.Pruitt,
L.Bostrom,
M.Wei,
R.Klabe,
L.Gonneville,
R.Wynn,
T.C.Burn,
P.C.C.Liu,
A.P.Combs,
E.W.Yue,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 7.00 / 2.20 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 67.080, 72.910, 88.190, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.8 / 26.1 |
Other elements in 2vex:
The structure of Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor
(pdb code 2vex). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor, PDB code: 2vex:
In total only one binding site of Fluorine was determined in the Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor, PDB code: 2vex:
Fluorine binding site 1 out of 1 in 2vex
Go back to
Fluorine Binding Sites List in 2vex
Fluorine binding site 1 out
of 1 in the Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Strucutre of Protein Tyrosine Phosphatase 1B in Complex with An Isothiazolidinone-Containing Inhibitor within 5.0Å range:
|
Reference:
B.Douty,
B.Wayland,
P.J.Ala,
M.J.Bower,
J.Pruitt,
L.Bostrom,
M.Wei,
R.Klabe,
L.Gonneville,
R.Wynn,
T.C.Burn,
P.C.C.Liu,
A.P.Combs,
E.W.Yue.
Isothiazolidinone Inhibitors of PTP1B Containing Imidazoles and Imidazolines Bioorg.Med.Chem.Lett. V. 18 66 2008.
ISSN: ISSN 0960-894X
PubMed: 18037290
DOI: 10.1016/J.BMCL.2007.11.012
Page generated: Wed Jul 31 16:08:59 2024
ISSN: ISSN 0960-894X
PubMed: 18037290
DOI: 10.1016/J.BMCL.2007.11.012
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