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Atomistry » Fluorine » PDB 2vh0-2wbk » 2vtn » |
Fluorine in PDB 2vtn: Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.Enzymatic activity of Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
All present enzymatic activity of Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.:
2.7.11.1; 2.7.11.22; Protein crystallography data
The structure of Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design., PDB code: 2vtn
was solved by
P.G.Wyatt,
A.J.Woodhead,
J.A.Boulstridge,
V.Berdini,
M.G.Carr,
D.M.Cross,
D.Danillon,
D.J.Davis,
L.A.Devine,
T.R.Early,
R.E.Feltell,
E.J.Lewis,
R.L.Mcmenamin,
E.F.Navarro,
M.A.O'brien,
M.O'reilly,
M.Reule,
G.Saxty,
L.C.A.Seavers,
D.Smith,
M.S.Squires,
G.Trewartha,
M.T.Walker,
A.J.Woolford,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
(pdb code 2vtn). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design., PDB code: 2vtn: Fluorine binding site 1 out of 1 in 2vtnGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
![]() Mono view ![]() Stereo pair view
Reference:
P.G.Wyatt,
A.J.Woodhead,
V.Berdini,
J.A.Boulstridge,
M.G.Carr,
D.M.Cross,
D.J.Davis,
L.A.Devine,
T.R.Early,
R.E.Feltell,
E.J.Lewis,
R.L.Mcmenamin,
E.F.Navarro,
M.A.O'brien,
M.O'reilly,
M.Reule,
G.Saxty,
L.C.A.Seavers,
D.Smith,
M.S.Squires,
G.Trewartha,
M.T.Walker,
A.J.Woolford.
Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino) -1H-Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design. J.Med.Chem. V. 51 4986 2008.
Page generated: Mon Jul 14 14:34:52 2025
ISSN: ISSN 0022-2623 PubMed: 18656911 DOI: 10.1021/JM800382H |
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