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Atomistry » Fluorine » PDB 2vh0-2wbk » 2vtt | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 2vh0-2wbk » 2vtt » |
Fluorine in PDB 2vtt: Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.Enzymatic activity of Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
All present enzymatic activity of Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.:
2.7.11.1; 2.7.11.22; Protein crystallography data
The structure of Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design., PDB code: 2vtt
was solved by
P.G.Wyatt,
A.J.Woodhead,
J.A.Boulstridge,
V.Berdini,
M.G.Carr,
D.M.Cross,
D.Danillon,
D.J.Davis,
L.A.Devine,
T.R.Early,
R.E.Feltell,
E.J.Lewis,
R.L.Mcmenamin,
E.F.Navarro,
M.A.O'brien,
M.O'reilly,
M.Reule,
G.Saxty,
L.C.A.Seavers,
D.Smith,
M.S.Squires,
G.Trewartha,
M.T.Walker,
A.J.Woolford,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
(pdb code 2vtt). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design., PDB code: 2vtt: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 2vttGo back to Fluorine Binding Sites List in 2vtt
Fluorine binding site 1 out
of 2 in the Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 2vttGo back to Fluorine Binding Sites List in 2vtt
Fluorine binding site 2 out
of 2 in the Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H- Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.
Mono view Stereo pair view
Reference:
P.G.Wyatt,
A.J.Woodhead,
V.Berdini,
J.A.Boulstridge,
M.G.Carr,
D.M.Cross,
D.J.Davis,
L.A.Devine,
T.R.Early,
R.E.Feltell,
E.J.Lewis,
R.L.Mcmenamin,
E.F.Navarro,
M.A.O'brien,
M.O'reilly,
M.Reule,
G.Saxty,
L.C.A.Seavers,
D.Smith,
M.S.Squires,
G.Trewartha,
M.T.Walker,
A.J.Woolford.
Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino) -1H-Pyrazole-3-Carboxamide (AT7519), A Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design. J.Med.Chem. V. 51 4986 2008.
Page generated: Wed Jul 31 16:19:24 2024
ISSN: ISSN 0022-2623 PubMed: 18656911 DOI: 10.1021/JM800382H |
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