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Atomistry » Fluorine » PDB 2vh0-2wbk » 2w1c » |
Fluorine in PDB 2w1c: Structure Determination of Aurora Kinase in Complex with InhibitorEnzymatic activity of Structure Determination of Aurora Kinase in Complex with Inhibitor
All present enzymatic activity of Structure Determination of Aurora Kinase in Complex with Inhibitor:
2.7.11.1; Protein crystallography data
The structure of Structure Determination of Aurora Kinase in Complex with Inhibitor, PDB code: 2w1c
was solved by
S.Howard,
V.Berdini,
J.A.Boulstridge,
M.G.Carr,
D.M.Cross,
J.Curry,
L.A.Devine,
T.R.Early,
L.Fazal,
A.L.Gill,
M.Heathcote,
S.Maman,
J.E.Matthews,
R.L.Mcmenamin,
E.F.Navarro,
M.A.O'brien,
M.O'reilly,
D.C.Rees,
M.Reule,
D.Tisi,
G.Williams,
M.Vinkovic,
P.G.Wyatt,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure Determination of Aurora Kinase in Complex with Inhibitor
(pdb code 2w1c). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure Determination of Aurora Kinase in Complex with Inhibitor, PDB code: 2w1c: Fluorine binding site 1 out of 1 in 2w1cGo back to Fluorine Binding Sites List in 2w1c
Fluorine binding site 1 out
of 1 in the Structure Determination of Aurora Kinase in Complex with Inhibitor
Mono view Stereo pair view
Reference:
S.Howard,
V.Berdini,
J.A.Boulstridge,
M.G.Carr,
D.M.Cross,
J.Curry,
L.A.Devine,
T.R.Early,
L.Fazal,
A.L.Gill,
M.Heathcote,
S.Maman,
J.E.Matthews,
R.L.Mcmenamin,
E.F.Navarro,
M.A.O'brien,
M.O'reilly,
D.C.Rees,
M.Reule,
D.Tisi,
G.Williams,
M.Vinkovic,
P.G.Wyatt.
Fragment-Based Discovery of the Pyrazol-4-Yl Urea (AT9283), A Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. J.Med.Chem. V. 52 379 2009.
Page generated: Sun Dec 13 11:40:49 2020
ISSN: ISSN 0022-2623 PubMed: 19143567 DOI: 10.1021/JM800984V |
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