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Fluorine in PDB 2w4o: Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl- Phenylamino)-Triazole-Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide)
Enzymatic activity of Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl- Phenylamino)-Triazole-Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide)
All present enzymatic activity of Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl- Phenylamino)-Triazole-Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide):
2.7.11.17;
2.7.11.17;
Protein crystallography data
The structure of Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl- Phenylamino)-Triazole-Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide), PDB code: 2w4o
was solved by
J.R.C.Muniz,
P.Rellos,
O.Gileadi,
O.Fedorov,
P.Filippakopoulos,
E.Salah,
A.Pike,
C.Phillips,
F.Niesen,
L.Shrestha,
N.Burgess-Brown,
A.Bullock,
G.Berridge,
F.Von Delft,
A.M.Edwards,
C.Bountra,
C.H.Arrowsmith,
J.Weigelt,
S.Knapp,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 36.38 / 2.17 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.400, 70.810, 99.151, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 21.4 / 23.7 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl- Phenylamino)-Triazole-Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide)
(pdb code 2w4o). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl- Phenylamino)-Triazole-Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide), PDB code: 2w4o:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl- Phenylamino)-Triazole-Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide), PDB code: 2w4o:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 2w4o
Go back to
Fluorine Binding Sites List in 2w4o
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl- Phenylamino)-Triazole-Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl- Phenylamino)-Triazole-Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide) within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 2w4o
Go back to
Fluorine Binding Sites List in 2w4o
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl- Phenylamino)-Triazole-Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl- Phenylamino)-Triazole-Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide) within 5.0Å range:
|
Reference:
J.R.C.Muniz,
P.Rellos,
O.Gileadi,
O.Fedorov,
P.Filippakopoulos,
E.Salah,
A.Pike,
C.Phillips,
F.Niesen,
L.Shrestha,
N.Burgess-Brown,
A.Bullock,
G.Berridge,
F.Von Delft,
A.M.Edwards,
C.Bountra,
C.H.Arrowsmith,
J.Weigelt,
S.Knapp.
Crystal Structure of Human CAMK4 in Complex with 4-Amino(Sulfamoyl-Phenylamino)-Triazole- Carbothioic Acid (2,6-Difluoro-Phenyl)-Amide) To Be Published.
Page generated: Sun Dec 13 11:40:51 2020
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