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PDB 2weg-2x2f »
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Fluorine in PDB 2wgj: X-Ray Structure of Pf-02341066 Bound to the Kinase Domain of C-Met
Enzymatic activity of X-Ray Structure of Pf-02341066 Bound to the Kinase Domain of C-Met
All present enzymatic activity of X-Ray Structure of Pf-02341066 Bound to the Kinase Domain of C-Met:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of X-Ray Structure of Pf-02341066 Bound to the Kinase Domain of C-Met, PDB code: 2wgj
was solved by
M.Mctigue,
N.Grodsky,
K.Ryan,
M.Tran-Dube,
J.J.Cui,
B.Mroczkowski,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 19.96 / 2.00 |
| Space group | P 21 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 76.926, 94.192, 45.990, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 21.4 / 23.2 |
Other elements in 2wgj:
The structure of X-Ray Structure of Pf-02341066 Bound to the Kinase Domain of C-Met also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the X-Ray Structure of Pf-02341066 Bound to the Kinase Domain of C-Met
(pdb code 2wgj). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the X-Ray Structure of Pf-02341066 Bound to the Kinase Domain of C-Met, PDB code: 2wgj:
In total only one binding site of Fluorine was determined in the X-Ray Structure of Pf-02341066 Bound to the Kinase Domain of C-Met, PDB code: 2wgj:
Fluorine binding site 1 out of 1 in 2wgj
Go back to
Fluorine Binding Sites List in 2wgj
Fluorine binding site 1 out
of 1 in the X-Ray Structure of Pf-02341066 Bound to the Kinase Domain of C-Met
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of X-Ray Structure of Pf-02341066 Bound to the Kinase Domain of C-Met within 5.0Å range:
|
Reference:
J.J.Cui,
M.Tran-Dube,
H.Shen,
M.Nambu,
P.P.Kung,
M.Pairish,
L.Jia,
J.Meng,
L.Funk,
I.Botrous,
M.Mctigue,
N.Grodsky,
K.Ryan,
E.Padrique,
G.Alton,
S.Timofeevski,
S.Yamazaki,
Q.Li,
H.Zou,
J.Christensen,
B.Mroczkowski,
S.Bender,
R.S.Kania,
M.P.Edwards.
Structure Based Drug Design of Crizotinib (Pf-02341066), A Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-Met) Kinase and Anaplastic Lymphoma Kinase (Alk). J.Med.Chem V. 54 6342 2011.
ISSN: ISSN 0022-2623
PubMed: 21812414
DOI: 10.1021/JM2007613
Page generated: Wed Jul 31 16:25:54 2024
ISSN: ISSN 0022-2623
PubMed: 21812414
DOI: 10.1021/JM2007613
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