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Fluorine in PDB 2wxg: The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with SW13.
Enzymatic activity of The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with SW13.
All present enzymatic activity of The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with SW13.:
2.7.1.153;
2.7.1.153;
Protein crystallography data
The structure of The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with SW13., PDB code: 2wxg
was solved by
A.Berndt,
S.Miller,
O.Williams,
D.D.Lee,
B.T.Houseman,
J.I.Pacold,
F.Gorrec,
W.-C.Hon,
Y.Liu,
C.Rommel,
P.Gaillard,
T.Ruckle,
M.K.Schwarz,
K.M.Shokat,
J.P.Shaw,
R.L.Williams,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 113.96 / 2.00 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 141.761, 64.675, 116.721, 90.00, 102.95, 90.00 |
| R / Rfree (%) | 20.6 / 24.3 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with SW13.
(pdb code 2wxg). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with SW13., PDB code: 2wxg:
In total only one binding site of Fluorine was determined in the The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with SW13., PDB code: 2wxg:
Fluorine binding site 1 out of 1 in 2wxg
Go back to
Fluorine Binding Sites List in 2wxg
Fluorine binding site 1 out
of 1 in the The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with SW13.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of The Crystal Structure of the Murine Class Ia Pi 3-Kinase P110DELTA in Complex with SW13. within 5.0Å range:
|
Reference:
A.Berndt,
S.Miller,
O.Williams,
D.D.Lee,
B.T.Houseman,
J.I.Pacold,
F.Gorrec,
W.-C.Hon,
Y.Liu,
C.Rommel,
P.Gaillard,
T.Ruckle,
M.K.Schwarz,
K.M.Shokat,
J.P.Shaw,
R.L.Williams.
The P110D Structure: Mechanisms For Selectivity and Potency of New Pi(3)K Inhibitors Nat.Chem.Biol. V. 6 117 2010.
ISSN: ISSN 1552-4450
PubMed: 20081827
DOI: 10.1038/NCHEMBIO.293
Page generated: Sun Dec 13 11:41:13 2020
ISSN: ISSN 1552-4450
PubMed: 20081827
DOI: 10.1038/NCHEMBIO.293
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