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Atomistry » Fluorine » PDB 2x2n-2y1w » 2x81 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 2x2n-2y1w » 2x81 » |
Fluorine in PDB 2x81: Structure of Aurora A in Complex with MLN8054Enzymatic activity of Structure of Aurora A in Complex with MLN8054
All present enzymatic activity of Structure of Aurora A in Complex with MLN8054:
2.7.11.1; Protein crystallography data
The structure of Structure of Aurora A in Complex with MLN8054, PDB code: 2x81
was solved by
W.Savory,
I.Mueller,
C.S.Mason,
M.Lamers,
D.H.Williams,
P.A.Eyers,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2x81:
The structure of Structure of Aurora A in Complex with MLN8054 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Aurora A in Complex with MLN8054
(pdb code 2x81). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Structure of Aurora A in Complex with MLN8054, PDB code: 2x81: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 2x81Go back to Fluorine Binding Sites List in 2x81
Fluorine binding site 1 out
of 2 in the Structure of Aurora A in Complex with MLN8054
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 2x81Go back to Fluorine Binding Sites List in 2x81
Fluorine binding site 2 out
of 2 in the Structure of Aurora A in Complex with MLN8054
Mono view Stereo pair view
Reference:
D.Sloane,
M.Trikic,
M.L.Chu,
M.Lamers,
C.S.Mason,
I.Mueller,
W.Savory,
D.H.Williams,
P.A.Eyers.
Drug-Resistant Aurora A Mutants For Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237. Acs Chem.Biol. V. 5 563 2010.
Page generated: Wed Jul 31 16:36:46 2024
ISSN: ISSN 1554-8929 PubMed: 20426425 DOI: 10.1021/CB100053Q |
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