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Atomistry » Fluorine » PDB 2x2n-2y1w » 2xhd | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 2x2n-2y1w » 2xhd » |
Fluorine in PDB 2xhd: Crystal Structure of N-((2S)-5-(6-Fluoro-3-Pyridinyl)-2,3- Dihydro-1H-Inden-2-Yl)-2-Propanesulfonamide in Complex with the Ligand Binding Domain of the Human GLUA2 ReceptorProtein crystallography data
The structure of Crystal Structure of N-((2S)-5-(6-Fluoro-3-Pyridinyl)-2,3- Dihydro-1H-Inden-2-Yl)-2-Propanesulfonamide in Complex with the Ligand Binding Domain of the Human GLUA2 Receptor, PDB code: 2xhd
was solved by
S.E.Ward,
M.Harries,
L.Aldegheri,
D.Andreotti,
S.Ballantine,
B.D.Bax,
A.J.Harris,
A.J.Harker,
J.Lund,
R.Melarange,
A.Mingardi,
C.Mookherjee,
J.Mosley,
M.Neve,
B.Oliosi,
R.Profeta,
K.J.Smith,
P.W.Smith,
S.Spada,
K.M.Thewlis,
S.P.Yusaf,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of N-((2S)-5-(6-Fluoro-3-Pyridinyl)-2,3- Dihydro-1H-Inden-2-Yl)-2-Propanesulfonamide in Complex with the Ligand Binding Domain of the Human GLUA2 Receptor
(pdb code 2xhd). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of N-((2S)-5-(6-Fluoro-3-Pyridinyl)-2,3- Dihydro-1H-Inden-2-Yl)-2-Propanesulfonamide in Complex with the Ligand Binding Domain of the Human GLUA2 Receptor, PDB code: 2xhd: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 2xhdGo back to Fluorine Binding Sites List in 2xhd
Fluorine binding site 1 out
of 2 in the Crystal Structure of N-((2S)-5-(6-Fluoro-3-Pyridinyl)-2,3- Dihydro-1H-Inden-2-Yl)-2-Propanesulfonamide in Complex with the Ligand Binding Domain of the Human GLUA2 Receptor
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 2xhdGo back to Fluorine Binding Sites List in 2xhd
Fluorine binding site 2 out
of 2 in the Crystal Structure of N-((2S)-5-(6-Fluoro-3-Pyridinyl)-2,3- Dihydro-1H-Inden-2-Yl)-2-Propanesulfonamide in Complex with the Ligand Binding Domain of the Human GLUA2 Receptor
Mono view Stereo pair view
Reference:
S.E.Ward,
M.Harries,
L.Aldegheri,
D.Andreotti,
S.Ballantine,
B.D.Bax,
A.J.Harris,
A.J.Harker,
J.Lund,
R.Melarange,
A.Mingardi,
C.Mookherjee,
J.Mosley,
M.Neve,
B.Oliosi,
R.Profeta,
K.J.Smith,
P.W.Smith,
S.Spada,
K.M.Thewlis,
S.P.Yusaf.
Discovery of N-[(2S)-5-(6-Fluoro-3-Pyridinyl)-2,3- Dihydro-1H-Inden-2-Yl]-2-Propanesulfonamide, A Novel Clinical Ampa Receptor Positive Modulator. J.Med.Chem. V. 53 5801 2010.
Page generated: Wed Jul 31 16:38:31 2024
ISSN: ISSN 0022-2623 PubMed: 20614889 DOI: 10.1021/JM1005429 |
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