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Atomistry » Fluorine » PDB 2x2n-2y1w » 2xnn | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 2x2n-2y1w » 2xnn » |
Fluorine in PDB 2xnn: Structure of NEK2 Bound to CCT242430Enzymatic activity of Structure of NEK2 Bound to CCT242430
All present enzymatic activity of Structure of NEK2 Bound to CCT242430:
2.7.11.1; Protein crystallography data
The structure of Structure of NEK2 Bound to CCT242430, PDB code: 2xnn
was solved by
C.Mas-Droux,
R.Bayliss,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2xnn:
The structure of Structure of NEK2 Bound to CCT242430 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of NEK2 Bound to CCT242430
(pdb code 2xnn). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Structure of NEK2 Bound to CCT242430, PDB code: 2xnn: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 2xnnGo back to Fluorine Binding Sites List in 2xnn
Fluorine binding site 1 out
of 3 in the Structure of NEK2 Bound to CCT242430
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 2xnnGo back to Fluorine Binding Sites List in 2xnn
Fluorine binding site 2 out
of 3 in the Structure of NEK2 Bound to CCT242430
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 2xnnGo back to Fluorine Binding Sites List in 2xnn
Fluorine binding site 3 out
of 3 in the Structure of NEK2 Bound to CCT242430
Mono view Stereo pair view
Reference:
S.Solanki,
P.Innocenti,
C.Mas-Droux,
K.Boxall,
C.Barillari,
R.L.Van Montfort,
G.W.Aherne,
R.Bayliss,
S.Hoelder.
Benzimidazole Inhibitors Induce A Dfg-Out Conformation of Never in Mitosis Gene A-Related Kinase 2 (NEK2) Without Binding to the Back Pocket and Reveal A Nonlinear Structure-Activity Relationship. J.Med.Chem. V. 54 1626 2011.
Page generated: Wed Jul 31 16:39:36 2024
ISSN: ISSN 0022-2623 PubMed: 21366329 DOI: 10.1021/JM1011726 |
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