Atomistry » Fluorine » PDB 2x2n-2y1w » 2xxh
Atomistry »
  Fluorine »
    PDB 2x2n-2y1w »
      2xxh »

Fluorine in PDB 2xxh: Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution.

Protein crystallography data

The structure of Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution., PDB code: 2xxh was solved by S.E.Ward, M.Harries, L.Aldegheri, N.E.Austin, S.Ballantine, E.Ballini, D.M.Bradley, B.D.Bax, B.P.Clarke, A.J.Harris, S.A.Harrison, R.A.Melarange, C.Mookherjee, J.Mosley, G.Dalnegro, B.Oliosi, K.J.Smith, K.M.Thewlis, P.M.Woollard, S.P.Yusaf, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.50
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 114.374, 163.583, 47.481, 90.00, 90.00, 90.00
R / Rfree (%) 19.367 / 21.757

Other elements in 2xxh:

The structure of Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution. also contains other interesting chemical elements:

Zinc (Zn) 5 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution. (pdb code 2xxh). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 9 binding sites of Fluorine where determined in the Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution., PDB code: 2xxh:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;

Fluorine binding site 1 out of 9 in 2xxh

Go back to Fluorine Binding Sites List in 2xxh
Fluorine binding site 1 out of 9 in the Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F310

b:21.9
occ:0.50
 F1 A:1NG310 0.0 21.9 0.5
O A:HOH2173 0.9 29.1 0.5
C2 A:1NG310 1.3 21.1 0.5
F3 A:1NG310 2.1 23.6 0.5
F4 A:1NG310 2.2 25.9 0.5
C5 A:1NG310 2.4 18.1 0.5
O C:HOH2149 2.8 34.8 0.5
N6 A:1NG310 2.9 17.0 0.5
O C:HOH2059 3.0 16.5 0.5
C13 A:1NG310 3.5 19.6 0.5
CB A:LYS104 3.5 16.3 1.0
O20 A:1NG310 3.7 26.7 0.5
CD2 A:LEU239 3.8 21.0 1.0
CG2 C:ILE92 3.8 15.4 1.0
CD A:PRO105 3.9 14.4 1.0
CG A:LYS104 3.9 19.7 1.0
CD A:LYS104 3.9 23.5 1.0
CD1 C:ILE92 4.0 14.7 1.0
N7 A:1NG310 4.1 18.6 0.5
CB C:ILE92 4.2 13.7 1.0
C12 A:1NG310 4.2 16.7 0.5
N A:PRO105 4.4 13.5 1.0
C8 A:1NG310 4.5 17.1 0.5
O A:PRO105 4.5 14.8 1.0
CA A:LYS104 4.5 14.6 1.0
CG A:PRO105 4.6 18.7 1.0
CG C:PRO105 4.6 17.2 1.0
CG1 C:ILE92 4.7 13.0 1.0
C A:LYS104 4.7 12.5 1.0
CD C:PRO105 4.8 13.9 1.0
N C:GLY219 4.9 13.4 1.0
CE A:LYS104 4.9 24.6 1.0

Fluorine binding site 2 out of 9 in 2xxh

Go back to Fluorine Binding Sites List in 2xxh
Fluorine binding site 2 out of 9 in the Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F310

b:23.6
occ:0.50
 F3 A:1NG310 0.0 23.6 0.5
O C:HOH2059 1.2 16.5 0.5
C2 A:1NG310 1.3 21.1 0.5
O A:HOH2173 1.7 29.1 0.5
F1 A:1NG310 2.1 21.9 0.5
F4 A:1NG310 2.1 25.9 0.5
C5 A:1NG310 2.3 18.1 0.5
N6 A:1NG310 2.8 17.0 0.5
N C:GLY219 2.9 13.4 1.0
CB C:ILE92 3.5 13.7 1.0
O20 A:1NG310 3.5 26.7 0.5
CA C:GLY219 3.5 13.3 1.0
C13 A:1NG310 3.6 19.6 0.5
O C:HOH2149 3.7 34.8 0.5
O C:GLY219 3.7 12.9 1.0
C C:LYS218 3.7 14.3 1.0
CD1 C:ILE92 3.8 14.7 1.0
CA C:LYS218 3.9 15.7 1.0
CG2 C:ILE92 3.9 15.4 1.0
CB C:LYS218 3.9 16.5 1.0
C C:GLY219 4.0 12.7 1.0
N7 A:1NG310 4.1 18.6 0.5
O C:ILE92 4.1 14.6 1.0
CG1 C:ILE92 4.2 13.0 1.0
C12 A:1NG310 4.3 16.7 0.5
C8 A:1NG310 4.4 17.1 0.5
CA C:ILE92 4.6 13.2 1.0
C C:ILE92 4.7 14.2 1.0
C19 A:1NG310 4.7 20.8 0.5
O C:LYS218 4.8 14.7 1.0
CD2 A:LEU239 4.8 21.0 1.0
N C:ILE92 4.8 12.3 1.0

Fluorine binding site 3 out of 9 in 2xxh

Go back to Fluorine Binding Sites List in 2xxh
Fluorine binding site 3 out of 9 in the Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F310

b:25.9
occ:0.50
 F4 A:1NG310 0.0 25.9 0.5
C2 A:1NG310 1.3 21.1 0.5
O C:HOH2149 2.0 34.8 0.5
O C:HOH2059 2.1 16.5 0.5
F3 A:1NG310 2.1 23.6 0.5
F1 A:1NG310 2.2 21.9 0.5
C5 A:1NG310 2.3 18.1 0.5
O A:HOH2173 2.5 29.1 0.5
C13 A:1NG310 2.9 19.6 0.5
C12 A:1NG310 2.9 16.7 0.5
O20 A:1NG310 3.1 26.7 0.5
CD2 A:LEU239 3.5 21.0 1.0
N6 A:1NG310 3.5 17.0 0.5
C19 A:1NG310 4.2 20.8 0.5
C8 A:1NG310 4.2 17.1 0.5
OG A:SER242 4.2 20.1 1.0
CB C:LYS218 4.4 16.5 1.0
CA C:LYS218 4.4 15.7 1.0
N7 A:1NG310 4.4 18.6 0.5
C11 A:1NG310 4.5 19.0 0.5
O C:ILE92 4.5 14.6 1.0
CG2 C:ILE92 4.5 15.4 1.0
N C:GLY219 4.6 13.4 1.0
C25 A:1NG310 4.6 22.8 0.5
O A:PRO105 4.6 14.8 1.0
CB A:SER242 4.8 15.4 1.0
CB C:ILE92 4.8 13.7 1.0
O A:HOH2153 4.8 24.3 1.0
N21 A:1NG310 4.9 23.1 0.5
C C:LYS218 4.9 14.3 1.0
CB A:LYS104 5.0 16.3 1.0
CG A:LEU239 5.0 18.1 1.0

Fluorine binding site 4 out of 9 in 2xxh

Go back to Fluorine Binding Sites List in 2xxh
Fluorine binding site 4 out of 9 in the Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F310

b:20.4
occ:0.50
 F1 A:1NG310 0.0 20.4 0.5
O C:HOH2148 0.9 26.6 0.5
C2 A:1NG310 1.3 19.2 0.5
O A:HOH2174 1.5 25.9 0.5
F4 A:1NG310 2.1 23.2 0.5
F3 A:1NG310 2.2 20.6 0.5
C5 A:1NG310 2.3 15.1 0.5
O A:HOH2140 2.8 18.7 0.5
N6 A:1NG310 3.0 12.8 0.5
C13 A:1NG310 3.4 14.2 0.5
O20 A:1NG310 3.6 32.8 0.5
CB C:LYS104 3.6 15.6 1.0
CD2 C:LEU239 3.9 21.3 1.0
CG2 A:ILE92 4.0 13.7 1.0
CD C:PRO105 4.0 13.9 1.0
CD C:LYS104 4.0 18.9 1.0
CG C:LYS104 4.0 18.6 1.0
C12 A:1NG310 4.0 10.4 0.5
CD1 A:ILE92 4.1 14.4 1.0
N7 A:1NG310 4.2 13.9 0.5
O C:PRO105 4.2 15.8 1.0
CB A:ILE92 4.3 14.1 1.0
CG C:PRO105 4.3 17.2 1.0
N C:PRO105 4.4 13.5 1.0
C8 A:1NG310 4.4 14.1 0.5
CG A:PRO105 4.6 18.7 1.0
CA C:LYS104 4.6 13.8 1.0
C19 A:1NG310 4.7 31.2 0.5
C C:LYS104 4.8 13.9 1.0
CG1 A:ILE92 4.8 12.2 1.0
N A:GLY219 4.9 13.3 1.0
CD A:PRO105 5.0 14.4 1.0
CE C:LYS104 5.0 22.5 1.0

Fluorine binding site 5 out of 9 in 2xxh

Go back to Fluorine Binding Sites List in 2xxh
Fluorine binding site 5 out of 9 in the Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F310

b:20.6
occ:0.50
 F3 A:1NG310 0.0 20.6 0.5
O A:HOH2140 1.2 18.7 0.5
C2 A:1NG310 1.3 19.2 0.5
O C:HOH2148 1.9 26.6 0.5
F4 A:1NG310 2.1 23.2 0.5
F1 A:1NG310 2.2 20.4 0.5
C5 A:1NG310 2.3 15.1 0.5
N6 A:1NG310 2.7 12.8 0.5
N A:GLY219 2.9 13.3 1.0
O A:HOH2174 3.0 25.9 0.5
CA A:GLY219 3.5 13.5 1.0
CB A:ILE92 3.5 14.1 1.0
C13 A:1NG310 3.6 14.2 0.5
C A:LYS218 3.7 13.0 1.0
CD1 A:ILE92 3.7 14.4 1.0
O A:GLY219 3.7 12.1 1.0
CA A:LYS218 3.8 15.4 1.0
CB A:LYS218 3.9 16.8 1.0
CG2 A:ILE92 3.9 13.7 1.0
O20 A:1NG310 3.9 32.8 0.5
C A:GLY219 4.0 11.7 1.0
N7 A:1NG310 4.0 13.9 0.5
CG1 A:ILE92 4.1 12.2 1.0
O A:ILE92 4.2 16.5 1.0
C12 A:1NG310 4.4 10.4 0.5
C8 A:1NG310 4.5 14.1 0.5
C19 A:1NG310 4.6 31.2 0.5
CA A:ILE92 4.6 12.3 1.0
O A:LYS218 4.7 13.9 1.0
CG A:PRO105 4.7 18.7 1.0
C A:ILE92 4.8 14.4 1.0
N A:ILE92 4.8 11.4 1.0
C16 A:1NG310 4.9 22.9 0.5
CD2 C:LEU239 5.0 21.3 1.0

Fluorine binding site 6 out of 9 in 2xxh

Go back to Fluorine Binding Sites List in 2xxh
Fluorine binding site 6 out of 9 in the Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F310

b:23.2
occ:0.50
 F4 A:1NG310 0.0 23.2 0.5
C2 A:1NG310 1.3 19.2 0.5
O A:HOH2174 1.7 25.9 0.5
O A:HOH2140 1.9 18.7 0.5
F1 A:1NG310 2.1 20.4 0.5
F3 A:1NG310 2.1 20.6 0.5
C5 A:1NG310 2.3 15.1 0.5
O C:HOH2148 2.7 26.6 0.5
C13 A:1NG310 2.9 14.2 0.5
C12 A:1NG310 3.0 10.4 0.5
O20 A:1NG310 3.5 32.8 0.5
N6 A:1NG310 3.5 12.8 0.5
CD2 C:LEU239 3.7 21.3 1.0
C19 A:1NG310 4.0 31.2 0.5
CB A:LYS218 4.1 16.8 1.0
CA A:LYS218 4.1 15.4 1.0
C8 A:1NG310 4.2 14.1 0.5
OG C:SER242 4.3 18.1 1.0
N A:GLY219 4.4 13.3 1.0
N7 A:1NG310 4.5 13.9 0.5
O A:ILE92 4.5 16.5 1.0
C11 A:1NG310 4.5 14.2 0.5
CG2 A:ILE92 4.5 13.7 1.0
C A:LYS218 4.7 13.0 1.0
O C:PRO105 4.7 15.8 1.0
CB A:ILE92 4.7 14.1 1.0
O C:HOH2137 4.7 25.5 1.0
O A:SER217 4.7 15.2 0.5
CB C:SER242 4.8 16.6 1.0
C25 A:1NG310 4.8 31.2 0.5
O A:SER217 4.8 15.8 0.5
N21 A:1NG310 4.9 31.8 0.5
O C:HOH2141 5.0 20.3 1.0

Fluorine binding site 7 out of 9 in 2xxh

Go back to Fluorine Binding Sites List in 2xxh
Fluorine binding site 7 out of 9 in the Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F310

b:17.4
occ:0.50
 F1 B:1NG310 0.0 17.4 0.5
C2 B:1NG310 1.3 17.9 0.5
O B:HOH2191 1.4 33.4 0.5
F3 B:1NG310 2.1 20.0 0.5
F4 B:1NG310 2.2 23.1 0.5
C5 B:1NG310 2.3 10.7 0.5
N6 B:1NG310 3.0 12.5 0.5
C13 B:1NG310 3.4 14.3 0.5
CB B:LYS104 3.6 10.8 1.0
CD2 B:LEU239 3.7 16.0 1.0
CD B:LYS104 4.0 16.1 1.0
CG B:LYS104 4.0 14.7 1.0
C12 B:1NG310 4.1 12.2 0.5
CD B:PRO105 4.1 12.1 1.0
N7 B:1NG310 4.1 12.3 0.5
O B:PRO105 4.3 11.7 1.0
C8 B:1NG310 4.4 14.4 0.5
N B:PRO105 4.5 11.6 1.0
CG B:PRO105 4.6 12.8 1.0
CA B:LYS104 4.7 10.6 1.0
C B:LYS104 4.8 10.7 1.0
CE B:LYS104 5.0 16.9 1.0

Fluorine binding site 8 out of 9 in 2xxh

Go back to Fluorine Binding Sites List in 2xxh
Fluorine binding site 8 out of 9 in the Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F310

b:20.0
occ:0.50
 F3 B:1NG310 0.0 20.0 0.5
C2 B:1NG310 1.3 17.9 0.5
O B:HOH2191 1.5 33.4 0.5
F4 B:1NG310 2.1 23.1 0.5
F1 B:1NG310 2.1 17.4 0.5
C5 B:1NG310 2.4 10.7 0.5
N6 B:1NG310 2.8 12.5 0.5
C13 B:1NG310 3.6 14.3 0.5
N7 B:1NG310 4.1 12.3 0.5
C12 B:1NG310 4.5 12.2 0.5
C8 B:1NG310 4.5 14.4 0.5
CD2 B:LEU239 4.9 16.0 1.0

Fluorine binding site 9 out of 9 in 2xxh

Go back to Fluorine Binding Sites List in 2xxh
Fluorine binding site 9 out of 9 in the Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Crystal Structure of 1-(4-(2-Oxo-2-(1-Pyrrolidinyl)Ethyl)Phenyl)-3- (Trifluoromethyl)-4,5,6,7-Tetrahydro-1H-Indazole in Complex with the Ligand Binding Domain of the Rat GLUA2 Receptor and Glutamate at 1.5A Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F310

b:23.1
occ:0.50
 F4 B:1NG310 0.0 23.1 0.5
C2 B:1NG310 1.3 17.9 0.5
F3 B:1NG310 2.1 20.0 0.5
F1 B:1NG310 2.2 17.4 0.5
C5 B:1NG310 2.3 10.7 0.5
O B:HOH2191 2.7 33.4 0.5
C13 B:1NG310 2.9 14.3 0.5
C12 B:1NG310 3.0 12.2 0.5
N6 B:1NG310 3.5 12.5 0.5
CD2 B:LEU239 3.8 16.0 1.0
OG B:SER242 4.2 15.7 1.0
C8 B:1NG310 4.2 14.4 0.5
N7 B:1NG310 4.4 12.3 0.5
C11 B:1NG310 4.6 13.0 0.5
O B:HOH2177 4.6 24.2 1.0
CB B:SER242 4.8 13.5 1.0
O B:PRO105 5.0 11.7 1.0

Reference:

S.E.Ward, M.Harries, L.Aldegheri, N.E.Austin, S.Ballantine, E.Ballini, D.M.Bradley, B.D.Bax, B.P.Clarke, A.J.Harris, S.A.Harrison, R.A.Melarange, C.Mookherjee, J.Mosley, G.Dal Negro, B.Oliosi, K.J.Smith, K.M.Thewlis, P.M.Woollard, S.P.Yusaf. Integration of Lead Optimization with Crystallography For A Membrane-Bound Ion Channel Target: Discovery of A New Class of Ampa Receptor Positive Allosteric Modulators. J.Med.Chem. V. 54 78 2011.
ISSN: ISSN 0022-2623
PubMed: 21128618
DOI: 10.1021/JM100679E
Page generated: Wed Jul 31 16:42:01 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy