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Fluorine in PDB 2y1w: Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor
Enzymatic activity of Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor
All present enzymatic activity of Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor:
2.1.1.125;
2.1.1.125;
Protein crystallography data
The structure of Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor, PDB code: 2y1w
was solved by
J.S.Sack,
S.Thieffine,
T.Bandiera,
M.Fasolini,
G.J.Duke,
L.Jayaraman,
K.F.Kish,
H.E.Klei,
A.V.Purandare,
P.Rosettani,
S.Troiani,
D.Xie,
J.A.Bertrand,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.88 / 2.10 |
| Space group | P 21 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.896, 98.471, 207.184, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.5 / 24.4 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor
(pdb code 2y1w). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor, PDB code: 2y1w:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor, PDB code: 2y1w:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 2y1w
Go back to
Fluorine Binding Sites List in 2y1w
Fluorine binding site 1 out
of 4 in the Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 2y1w
Go back to
Fluorine Binding Sites List in 2y1w
Fluorine binding site 2 out
of 4 in the Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 2y1w
Go back to
Fluorine Binding Sites List in 2y1w
Fluorine binding site 3 out
of 4 in the Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 2y1w
Go back to
Fluorine Binding Sites List in 2y1w
Fluorine binding site 4 out
of 4 in the Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in Complex with Sinefungin and Indole Inhibitor within 5.0Å range:
|
Reference:
J.S.Sack,
S.Thieffine,
T.Bandiera,
M.Fasolini,
G.J.Duke,
L.Jayaraman,
K.F.Kish,
H.E.Klei,
A.V.Purandare,
P.Rosettani,
S.Troiani,
D.Xie,
J.A.Bertrand.
Structural Basis For CARM1 Inhibition By Indole and Pyrazole Inhibitors Biochem.J. V. 436 331 2011.
ISSN: ISSN 0264-6021
PubMed: 21410432
DOI: 10.1042/BJ20102161
Page generated: Wed Jul 31 16:43:45 2024
ISSN: ISSN 0264-6021
PubMed: 21410432
DOI: 10.1042/BJ20102161
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