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Atomistry » Fluorine » PDB 2y1x-2z5z » 2yfx | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 2y1x-2z5z » 2yfx » |
Fluorine in PDB 2yfx: Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with CrizotinibEnzymatic activity of Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
All present enzymatic activity of Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib:
2.7.10.1; Protein crystallography data
The structure of Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib, PDB code: 2yfx
was solved by
M.Mctigue,
Y.Deng,
W.Liu,
A.Brooun,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2yfx:
The structure of Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
(pdb code 2yfx). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib, PDB code: 2yfx: Fluorine binding site 1 out of 1 in 2yfxGo back to Fluorine Binding Sites List in 2yfx
Fluorine binding site 1 out
of 1 in the Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
Mono view Stereo pair view
Reference:
Q.Huang,
T.W.Johnson,
S.Bailey,
A.Brooun,
K.D.Bunker,
B.J.Burke,
M.R.Collins,
A.S.Cook,
J.J.Cui,
K.N.Dack,
J.G.Deal,
Y.Deng,
D.Dinh,
L.D.Engstrom,
M.He,
J.Hoffman,
R.L.Hoffman,
P.S.Johnson,
R.S.Kania,
H.Lam,
J.L.Lam,
P.T.Le,
Q.Li,
L.Lingardo,
W.Liu,
M.W.Lu,
M.Mctigue,
C.L.Palmer,
P.F.Richardson,
N.W.Sach,
H.Shen,
T.Smeal,
G.L.Smith,
A.E.Stewart,
S.Timofeevski,
K.Tsaparikos,
H.Wang,
H.Zhu,
J.Zhu,
H.Y.Zou,
M.P.Edwards.
Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib. J.Med.Chem. V. 57 1170 2014.
Page generated: Sun Dec 13 11:42:17 2020
ISSN: ISSN 0022-2623 PubMed: 24432909 DOI: 10.1021/JM401805H |
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