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Fluorine in PDB 2ynf: Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560
Enzymatic activity of Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560
All present enzymatic activity of Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13;
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13;
Protein crystallography data
The structure of Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560, PDB code: 2ynf
was solved by
P.Chong,
P.Sebahar,
M.Youngman,
D.Garrido,
H.Zhang,
E.L.Stewart,
R.T.Nolte,
L.Wang,
R.G.Ferris,
M.Edelstein,
K.Weaver,
A.Mathis,
A.Peat,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 47.57 / 2.36 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 119.578, 154.508, 157.026, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.722 / 23.631 |
Other elements in 2ynf:
The structure of Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560 also contains other interesting chemical elements:
| Magnesium | (Mg) | 3 atoms |
| Bromine | (Br) | 1 atom |
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560
(pdb code 2ynf). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560, PDB code: 2ynf:
In total only one binding site of Fluorine was determined in the Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560, PDB code: 2ynf:
Fluorine binding site 1 out of 1 in 2ynf
Go back to
Fluorine Binding Sites List in 2ynf
Fluorine binding site 1 out
of 1 in the Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Hiv-1 Reverse Transcriptase Y188L Mutant in Complex with Inhibitor GSK560 within 5.0Å range:
|
Reference:
P.Chong,
P.Sebahar,
M.Youngman,
D.Garrido,
H.Zhang,
E.L.Stewart,
R.T.Nolte,
L.Wang,
R.G.Ferris,
M.Edelstein,
K.Weaver,
A.Mathis,
A.Peat.
Rational Design of Potent Non-Nucleoside Inhibitors of Hiv- 1 Reverse Transcriptase. J.Med.Chem. V. 55 10601 2012.
ISSN: ISSN 0022-2623
PubMed: 23137340
DOI: 10.1021/JM301294G
Page generated: Wed Jul 31 16:53:54 2024
ISSN: ISSN 0022-2623
PubMed: 23137340
DOI: 10.1021/JM301294G
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