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Fluorine in PDB 3bgl: Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors
Enzymatic activity of Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors
All present enzymatic activity of Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors:
1.1.1.34;
1.1.1.34;
Protein crystallography data
The structure of Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors, PDB code: 3bgl
was solved by
B.C.Finzel,
A.Pavlovsky,
W.K.C.Park,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 2.23 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 71.588, 172.156, 75.148, 90.00, 117.24, 90.00 |
| R / Rfree (%) | 20.8 / 25.1 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors
(pdb code 3bgl). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors, PDB code: 3bgl:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors, PDB code: 3bgl:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 3bgl
Go back to
Fluorine Binding Sites List in 3bgl
Fluorine binding site 1 out
of 4 in the Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 3bgl
Go back to
Fluorine Binding Sites List in 3bgl
Fluorine binding site 2 out
of 4 in the Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 3bgl
Go back to
Fluorine Binding Sites List in 3bgl
Fluorine binding site 3 out
of 4 in the Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 3bgl
Go back to
Fluorine Binding Sites List in 3bgl
Fluorine binding site 4 out
of 4 in the Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors within 5.0Å range:
|
Reference:
W.K.Park,
R.M.Kennedy,
S.D.Larsen,
S.Miller,
B.D.Roth,
Y.Song,
B.A.Steinbaugh,
K.Sun,
B.D.Tait,
M.C.Kowala,
B.K.Trivedi,
B.Auerbach,
V.Askew,
L.Dillon,
J.C.Hanselman,
Z.Lin,
G.H.Lu,
A.Robertson,
C.Sekerke.
Hepatoselectivity of Statins: Design and Synthesis of 4-Sulfamoyl Pyrroles As Hmg-Coa Reductase Inhibitors. Bioorg.Med.Chem.Lett. V. 18 1151 2008.
ISSN: ISSN 0960-894X
PubMed: 18155906
DOI: 10.1016/J.BMCL.2007.11.124
Page generated: Mon Jul 14 15:19:21 2025
ISSN: ISSN 0960-894X
PubMed: 18155906
DOI: 10.1016/J.BMCL.2007.11.124
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