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Fluorine in PDB 3c1x: Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Pyrrolotriazine Based Inhibitor
Enzymatic activity of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Pyrrolotriazine Based Inhibitor
All present enzymatic activity of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Pyrrolotriazine Based Inhibitor:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Pyrrolotriazine Based Inhibitor, PDB code: 3c1x
was solved by
J.Sack,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 37.76 / 2.17 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.781, 46.153, 151.022, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.5 / 26.2 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Pyrrolotriazine Based Inhibitor
(pdb code 3c1x). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Pyrrolotriazine Based Inhibitor, PDB code: 3c1x:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Pyrrolotriazine Based Inhibitor, PDB code: 3c1x:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 3c1x
Go back to
Fluorine Binding Sites List in 3c1x
Fluorine binding site 1 out
of 2 in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Pyrrolotriazine Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Pyrrolotriazine Based Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 3c1x
Go back to
Fluorine Binding Sites List in 3c1x
Fluorine binding site 2 out
of 2 in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Pyrrolotriazine Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Pyrrolotriazine Based Inhibitor within 5.0Å range:
|
Reference:
G.M.Schroeder,
X.T.Chen,
D.K.Williams,
D.S.Nirschl,
Z.W.Cai,
D.Wei,
J.S.Tokarski,
Y.An,
J.Sack,
Z.Chen,
T.Huynh,
W.Vaccaro,
M.Poss,
B.Wautlet,
J.Gullo-Brown,
K.Kellar,
V.Manne,
J.T.Hunt,
T.W.Wong,
L.J.Lombardo,
J.Fargnoli,
R.M.Borzilleri.
Identification of Pyrrolo[2,1-F][1,2,4]Triazine-Based Inhibitors of Met Kinase. Bioorg.Med.Chem.Lett. V. 18 1945 2008.
ISSN: ISSN 0960-894X
PubMed: 18289854
DOI: 10.1016/J.BMCL.2008.01.121
Page generated: Wed Jul 31 17:20:14 2024
ISSN: ISSN 0960-894X
PubMed: 18289854
DOI: 10.1016/J.BMCL.2008.01.121
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