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Atomistry » Fluorine » PDB 3b0q-3cct » 3c45 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 3b0q-3cct » 3c45 » |
Fluorine in PDB 3c45: Human Dipeptidyl Peptidase IV/CD26 in Complex with A Fluoroolefin InhibitorEnzymatic activity of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Fluoroolefin Inhibitor
All present enzymatic activity of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Fluoroolefin Inhibitor:
3.4.14.5; Protein crystallography data
The structure of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Fluoroolefin Inhibitor, PDB code: 3c45
was solved by
G.Scapin,
S.D.Edmondson,
A.E.Weber,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3c45:
The structure of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Fluoroolefin Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A Fluoroolefin Inhibitor
(pdb code 3c45). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A Fluoroolefin Inhibitor, PDB code: 3c45: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 3c45Go back to Fluorine Binding Sites List in 3c45
Fluorine binding site 1 out
of 2 in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A Fluoroolefin Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 3c45Go back to Fluorine Binding Sites List in 3c45
Fluorine binding site 2 out
of 2 in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A Fluoroolefin Inhibitor
Mono view Stereo pair view
Reference:
S.D.Edmondson,
L.Wei,
J.Xu,
J.Shang,
S.Xu,
J.Pang,
A.Chaudhary,
D.C.Dean,
H.He,
B.Leiting,
K.A.Lyons,
R.A.Patel,
S.B.Patel,
G.Scapin,
J.K.Wu,
M.G.Beconi,
N.A.Thornberry,
A.E.Weber.
Fluoroolefins As Amide Bond Mimics in Dipeptidyl Peptidase IV Inhibitors Bioorg.Med.Chem.Lett. V. 18 2409 2008.
Page generated: Wed Jul 31 17:21:09 2024
ISSN: ISSN 0960-894X PubMed: 18331795 DOI: 10.1016/J.BMCL.2008.02.050 |
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