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Fluorine in PDB 3cst: Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2
Enzymatic activity of Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2
All present enzymatic activity of Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2:
2.7.1.153;
2.7.1.153;
Protein crystallography data
The structure of Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2, PDB code: 3cst
was solved by
P.Xie,
R.Marmorstein,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 3.20 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 145.114, 68.318, 107.029, 90.00, 95.14, 90.00 |
| R / Rfree (%) | 26.4 / 30.5 |
Other elements in 3cst:
The structure of Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2 also contains other interesting chemical elements:
| Ruthenium | (Ru) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2
(pdb code 3cst). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2, PDB code: 3cst:
In total only one binding site of Fluorine was determined in the Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2, PDB code: 3cst:
Fluorine binding site 1 out of 1 in 3cst
Go back to
Fluorine Binding Sites List in 3cst
Fluorine binding site 1 out
of 1 in the Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2 within 5.0Å range:
|
Reference:
P.Xie,
D.S.Williams,
G.E.Atilla-Gokcumen,
L.Milk,
M.Xiao,
K.S.Smalley,
M.Herlyn,
E.Meggers,
R.Marmorstein.
Structure-Based Design of An Organoruthenium Phosphatidyl-Inositol-3-Kinase Inhibitor Reveals A Switch Governing Lipid Kinase Potency and Selectivity. Acs Chem.Biol. V. 3 305 2008.
ISSN: ISSN 1554-8929
PubMed: 18484710
DOI: 10.1021/CB800039Y
Page generated: Sun Dec 13 11:44:11 2020
ISSN: ISSN 1554-8929
PubMed: 18484710
DOI: 10.1021/CB800039Y
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