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Fluorine in PDB 3cth: Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Aminopyridine Based Inhibitor
Enzymatic activity of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Aminopyridine Based Inhibitor
All present enzymatic activity of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Aminopyridine Based Inhibitor:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Aminopyridine Based Inhibitor, PDB code: 3cth
was solved by
J.Sack,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 15.25 / 2.30 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.752, 47.637, 152.471, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.7 / 27.3 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Aminopyridine Based Inhibitor
(pdb code 3cth). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Aminopyridine Based Inhibitor, PDB code: 3cth:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Aminopyridine Based Inhibitor, PDB code: 3cth:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 3cth
Go back to
Fluorine Binding Sites List in 3cth
Fluorine binding site 1 out
of 2 in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Aminopyridine Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Aminopyridine Based Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 3cth
Go back to
Fluorine Binding Sites List in 3cth
Fluorine binding site 2 out
of 2 in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Aminopyridine Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Aminopyridine Based Inhibitor within 5.0Å range:
|
Reference:
Z.-W.Cai,
D.Wei,
G.M.Schroeder,
L.A.Cornelius,
K.Kim,
X.-T.Chen,
R.J.Schmidt,
D.K.Williams,
J.S.Tokarski,
Y.An,
J.S.Sack,
V.Manne,
A.Kamath,
Y.Zhang,
P.Marathe,
J.T.Hunt,
L.J.Lombardo,
J.Fargnoli,
R.M.Borzilleri.
Discovery of Orally Active Pyrrolopyridine- and Aminopyridine-Based Met Kinase Inhibitors Bioorg.Med.Chem.Lett. V. 18 3224 2008.
ISSN: ISSN 0960-894X
PubMed: 18479916
DOI: 10.1016/J.BMCL.2008.04.047
Page generated: Wed Jul 31 17:36:18 2024
ISSN: ISSN 0960-894X
PubMed: 18479916
DOI: 10.1016/J.BMCL.2008.04.047
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