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Fluorine in PDB 3d4l: Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor
Enzymatic activity of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor
All present enzymatic activity of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor:
3.4.14.5;
3.4.14.5;
Protein crystallography data
The structure of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor, PDB code: 3d4l
was solved by
G.Scapin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 2.00 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 118.435, 125.749, 137.175, 90.00, 90.00, 90.00 |
| R / Rfree (%) | n/a / n/a |
Other elements in 3d4l:
The structure of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor also contains other interesting chemical elements:
| Sodium | (Na) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor
(pdb code 3d4l). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor, PDB code: 3d4l:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor, PDB code: 3d4l:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 3d4l
Go back to
Fluorine Binding Sites List in 3d4l
Fluorine binding site 1 out
of 4 in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 3d4l
Go back to
Fluorine Binding Sites List in 3d4l
Fluorine binding site 2 out
of 4 in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 3d4l
Go back to
Fluorine Binding Sites List in 3d4l
Fluorine binding site 3 out
of 4 in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 3d4l
Go back to
Fluorine Binding Sites List in 3d4l
Fluorine binding site 4 out
of 4 in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Human Dipeptidyl Peptidase IV/CD26 in Complex with A Novel Inhibitor within 5.0Å range:
|
Reference:
G.B.Liang,
X.Qian,
T.Biftu,
S.Singh,
Y.D.Gao,
G.Scapin,
S.Patel,
B.Leiting,
R.Patel,
J.Wu,
X.Zhang,
N.A.Thornberry,
A.E.Weber.
Discovery of New Binding Elements in Dpp-4 Inhibition and Their Applications in Novel Dpp-4 Inhibitor Design. Bioorg.Med.Chem.Lett. V. 18 3706 2008.
ISSN: ISSN 0960-894X
PubMed: 18524582
DOI: 10.1016/J.BMCL.2008.05.061
Page generated: Sun Dec 13 11:44:32 2020
ISSN: ISSN 0960-894X
PubMed: 18524582
DOI: 10.1016/J.BMCL.2008.05.061
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