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Fluorine in PDB 3dhf: Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate
Enzymatic activity of Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate
All present enzymatic activity of Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate:
2.4.2.12;
2.4.2.12;
Protein crystallography data
The structure of Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate, PDB code: 3dhf
was solved by
M.Ho,
E.S.Burgos,
S.C.Almo,
V.L.Schramm,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 25.87 / 1.80 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 60.993, 106.406, 83.403, 90.00, 96.93, 90.00 |
| R / Rfree (%) | 16 / 19.6 |
Other elements in 3dhf:
The structure of Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate also contains other interesting chemical elements:
| Magnesium | (Mg) | 4 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate
(pdb code 3dhf). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate, PDB code: 3dhf:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate, PDB code: 3dhf:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 3dhf
Go back to
Fluorine Binding Sites List in 3dhf
Fluorine binding site 1 out
of 6 in the Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 3dhf
Go back to
Fluorine Binding Sites List in 3dhf
Fluorine binding site 2 out
of 6 in the Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 3dhf
Go back to
Fluorine Binding Sites List in 3dhf
Fluorine binding site 3 out
of 6 in the Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 3dhf
Go back to
Fluorine Binding Sites List in 3dhf
Fluorine binding site 4 out
of 6 in the Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 3dhf
Go back to
Fluorine Binding Sites List in 3dhf
Fluorine binding site 5 out
of 6 in the Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 3dhf
Go back to
Fluorine Binding Sites List in 3dhf
Fluorine binding site 6 out
of 6 in the Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of Phosphorylated Mimic Form of Human Nampt Complexed with Nicotinamide Mononucleotide and Pyrophosphate within 5.0Å range:
|
Reference:
E.S.Burgos,
M.C.Ho,
S.C.Almo,
V.L.Schramm.
A Phosphoenzyme Mimic, Overlapping Catalytic Sites and Reaction Coordinate Motion For Human Nampt. Proc.Natl.Acad.Sci.Usa V. 106 13748 2009.
ISSN: ISSN 0027-8424
PubMed: 19666527
DOI: 10.1073/PNAS.0903898106
Page generated: Wed Jul 31 17:55:30 2024
ISSN: ISSN 0027-8424
PubMed: 19666527
DOI: 10.1073/PNAS.0903898106
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