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Fluorine in PDB 3dtw: Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor
Enzymatic activity of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor
All present enzymatic activity of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor, PDB code: 3dtw
was solved by
D.A.Whittington,
A.M.Long,
P.Rose,
Y.Gu,
H.Zhao,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 2.90 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 55.244, 68.355, 88.485, 90.00, 92.16, 90.00 |
| R / Rfree (%) | 21.5 / 27.9 |
Other elements in 3dtw:
The structure of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor
(pdb code 3dtw). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor, PDB code: 3dtw:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor, PDB code: 3dtw:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 3dtw
Go back to
Fluorine Binding Sites List in 3dtw
Fluorine binding site 1 out
of 6 in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 3dtw
Go back to
Fluorine Binding Sites List in 3dtw
Fluorine binding site 2 out
of 6 in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 3dtw
Go back to
Fluorine Binding Sites List in 3dtw
Fluorine binding site 3 out
of 6 in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 3dtw
Go back to
Fluorine Binding Sites List in 3dtw
Fluorine binding site 4 out
of 6 in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 3dtw
Go back to
Fluorine Binding Sites List in 3dtw
Fluorine binding site 5 out
of 6 in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 3dtw
Go back to
Fluorine Binding Sites List in 3dtw
Fluorine binding site 6 out
of 6 in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A Benzisoxazole Inhibitor within 5.0Å range:
|
Reference:
R.K.Kunz,
S.Rumfelt,
N.Chen,
D.Zhang,
A.S.Tasker,
R.Burli,
R.Hungate,
V.Yu,
Y.Nguyen,
D.A.Whittington,
K.L.Meagher,
M.Plant,
Y.Tudor,
M.Schrag,
Y.Xu,
G.Y.Ng,
E.Hu.
Discovery of Amido-Benzisoxazoles As Potent C-Kit Inhibitors. Bioorg.Med.Chem.Lett. V. 18 5115 2008.
ISSN: ISSN 0960-894X
PubMed: 18723346
DOI: 10.1016/J.BMCL.2008.07.111
Page generated: Sun Dec 13 11:45:07 2020
ISSN: ISSN 0960-894X
PubMed: 18723346
DOI: 10.1016/J.BMCL.2008.07.111
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