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Fluorine in PDB 3eqg: X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P
Enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P
All present enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P:
2.7.12.2;
2.7.12.2;
Protein crystallography data
The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P, PDB code: 3eqg
was solved by
T.O.Fischmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 16.54 / 2.50 |
| Space group | P 61 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 76.000, 76.000, 222.320, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 20.7 / 27.3 |
Other elements in 3eqg:
The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
| Iodine | (I) | 1 atom |
| Calcium | (Ca) | 1 atom |
| Sodium | (Na) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P
(pdb code 3eqg). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P, PDB code: 3eqg:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P, PDB code: 3eqg:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 3eqg
Go back to
Fluorine Binding Sites List in 3eqg
Fluorine binding site 1 out
of 3 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 3eqg
Go back to
Fluorine Binding Sites List in 3eqg
Fluorine binding site 2 out
of 3 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 3eqg
Go back to
Fluorine Binding Sites List in 3eqg
Fluorine binding site 3 out
of 3 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Ternary Complex with Pd, Adp and MG2P within 5.0Å range:
|
Reference:
T.O.Fischmann,
C.K.Smith,
T.W.Mayhood,
J.E.Myers,
P.Reichert,
A.Mannarino,
D.Carr,
H.Zhu,
J.Wong,
R.S.Yang,
H.V.Le,
V.S.Madison.
Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry V. 48 2661 2009.
ISSN: ISSN 0006-2960
PubMed: 19161339
DOI: 10.1021/BI801898E
Page generated: Wed Jul 31 18:20:43 2024
ISSN: ISSN 0006-2960
PubMed: 19161339
DOI: 10.1021/BI801898E
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