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Atomistry » Fluorine » PDB 3fls-3g70 » 3fls » |
Fluorine in PDB 3fls: P38 Kinase Crystal Structure in Complex with 6-(2,4-Difluoro-Phenoxy)- 2-((R)-2-Methanesulfonyl-1-Methyl-Ethylamino)-8-Methyl-8H-Pyrido[2,3- D]Pyrimidin-7-OneEnzymatic activity of P38 Kinase Crystal Structure in Complex with 6-(2,4-Difluoro-Phenoxy)- 2-((R)-2-Methanesulfonyl-1-Methyl-Ethylamino)-8-Methyl-8H-Pyrido[2,3- D]Pyrimidin-7-One
All present enzymatic activity of P38 Kinase Crystal Structure in Complex with 6-(2,4-Difluoro-Phenoxy)- 2-((R)-2-Methanesulfonyl-1-Methyl-Ethylamino)-8-Methyl-8H-Pyrido[2,3- D]Pyrimidin-7-One:
2.7.11.24; Protein crystallography data
The structure of P38 Kinase Crystal Structure in Complex with 6-(2,4-Difluoro-Phenoxy)- 2-((R)-2-Methanesulfonyl-1-Methyl-Ethylamino)-8-Methyl-8H-Pyrido[2,3- D]Pyrimidin-7-One, PDB code: 3fls
was solved by
A.Kuglstatter,
M.Ghate,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the P38 Kinase Crystal Structure in Complex with 6-(2,4-Difluoro-Phenoxy)- 2-((R)-2-Methanesulfonyl-1-Methyl-Ethylamino)-8-Methyl-8H-Pyrido[2,3- D]Pyrimidin-7-One
(pdb code 3fls). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the P38 Kinase Crystal Structure in Complex with 6-(2,4-Difluoro-Phenoxy)- 2-((R)-2-Methanesulfonyl-1-Methyl-Ethylamino)-8-Methyl-8H-Pyrido[2,3- D]Pyrimidin-7-One, PDB code: 3fls: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 3flsGo back to Fluorine Binding Sites List in 3fls
Fluorine binding site 1 out
of 2 in the P38 Kinase Crystal Structure in Complex with 6-(2,4-Difluoro-Phenoxy)- 2-((R)-2-Methanesulfonyl-1-Methyl-Ethylamino)-8-Methyl-8H-Pyrido[2,3- D]Pyrimidin-7-One
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 3flsGo back to Fluorine Binding Sites List in 3fls
Fluorine binding site 2 out
of 2 in the P38 Kinase Crystal Structure in Complex with 6-(2,4-Difluoro-Phenoxy)- 2-((R)-2-Methanesulfonyl-1-Methyl-Ethylamino)-8-Methyl-8H-Pyrido[2,3- D]Pyrimidin-7-One
Mono view Stereo pair view
Reference:
M.Soth,
A.Kuglstatter,
D.Goldstein.
The Discovery of Pamapimod, R1503 and R1487 As Orally Bioavailable and Highly Selective Inhibitors of P38 Map Kinase To Be Published.
Page generated: Wed Jul 31 18:38:42 2024
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