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Atomistry » Fluorine » PDB 3fls-3g70 » 3g0f » |
Fluorine in PDB 3g0f: Kit Kinase Domain Mutant D816H in Complex with SunitinibEnzymatic activity of Kit Kinase Domain Mutant D816H in Complex with Sunitinib
All present enzymatic activity of Kit Kinase Domain Mutant D816H in Complex with Sunitinib:
2.7.10.1; Protein crystallography data
The structure of Kit Kinase Domain Mutant D816H in Complex with Sunitinib, PDB code: 3g0f
was solved by
K.S.Gajiwala,
J.C.Wu,
E.A.Lunney,
G.D.Demetri,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Kit Kinase Domain Mutant D816H in Complex with Sunitinib
(pdb code 3g0f). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Kit Kinase Domain Mutant D816H in Complex with Sunitinib, PDB code: 3g0f: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 3g0fGo back to Fluorine Binding Sites List in 3g0f
Fluorine binding site 1 out
of 2 in the Kit Kinase Domain Mutant D816H in Complex with Sunitinib
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 3g0fGo back to Fluorine Binding Sites List in 3g0f
Fluorine binding site 2 out
of 2 in the Kit Kinase Domain Mutant D816H in Complex with Sunitinib
Mono view Stereo pair view
Reference:
K.S.Gajiwala,
J.C.Wu,
J.Christensen,
G.D.Deshmukh,
W.Diehl,
J.P.Dinitto,
J.M.English,
M.J.Greig,
Y.A.He,
S.L.Jacques,
E.A.Lunney,
M.Mctigue,
D.Molina,
T.Quenzer,
P.A.Wells,
X.Yu,
Y.Zhang,
A.Zou,
M.R.Emmett,
A.G.Marshall,
H.M.Zhang,
G.D.Demetri.
Kit Kinase Mutants Show Unique Mechanisms of Drug Resistance to Imatinib and Sunitinib in Gastrointestinal Stromal Tumor Patients. Proc.Natl.Acad.Sci.Usa V. 106 1542 2009.
Page generated: Sun Dec 13 11:46:29 2020
ISSN: ISSN 0027-8424 PubMed: 19164557 DOI: 10.1073/PNAS.0812413106 |
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