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Fluorine in PDB 3g1v: Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate
Enzymatic activity of Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate
All present enzymatic activity of Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate:
4.1.1.23;
4.1.1.23;
Protein crystallography data
The structure of Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate, PDB code: 3g1v
was solved by
A.A.Fedorov,
E.V.Fedorov,
K.K.Chan,
J.A.Gerlt,
S.C.Almo,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 24.93 / 1.30 |
| Space group | P 41 |
| Cell size a, b, c (Å), α, β, γ (°) | 56.620, 56.620, 127.443, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.3 / 21.1 |
Other elements in 3g1v:
The structure of Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate also contains other interesting chemical elements:
| Chlorine | (Cl) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate
(pdb code 3g1v). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate, PDB code: 3g1v:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate, PDB code: 3g1v:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 3g1v
Go back to
Fluorine Binding Sites List in 3g1v
Fluorine binding site 1 out
of 2 in the Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 3g1v
Go back to
Fluorine Binding Sites List in 3g1v
Fluorine binding site 2 out
of 2 in the Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Mutant D70G of Orotidine 5'- Monophosphate Decarboxylase From Methanobacterium Thermoautotrophicum Complexed with 5-Fluorouridine 5'- Monophosphate within 5.0Å range:
|
Reference:
K.K.Chan,
B.M.Wood,
A.A.Fedorov,
E.V.Fedorov,
H.J.Imker,
T.L.Amyes,
J.P.Richard,
S.C.Almo,
J.A.Gerlt.
Mechanism of the Orotidine 5'-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence For Substrate Destabilization. Biochemistry V. 48 5518 2009.
ISSN: ISSN 0006-2960
PubMed: 19435314
DOI: 10.1021/BI900623R
Page generated: Wed Jul 31 18:43:11 2024
ISSN: ISSN 0006-2960
PubMed: 19435314
DOI: 10.1021/BI900623R
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