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Atomistry » Fluorine » PDB 3g72-3gwv » 3g9n » |
Fluorine in PDB 3g9n: JNK3 Bound to (Z)-1-((6-Fluoro-4H-Benzo[D][1,3]Dioxin-8-Yl)Methyl)-3- (Hydroxyimino)-4-Phenylindolin-2-OneEnzymatic activity of JNK3 Bound to (Z)-1-((6-Fluoro-4H-Benzo[D][1,3]Dioxin-8-Yl)Methyl)-3- (Hydroxyimino)-4-Phenylindolin-2-One
All present enzymatic activity of JNK3 Bound to (Z)-1-((6-Fluoro-4H-Benzo[D][1,3]Dioxin-8-Yl)Methyl)-3- (Hydroxyimino)-4-Phenylindolin-2-One:
2.7.11.24; Protein crystallography data
The structure of JNK3 Bound to (Z)-1-((6-Fluoro-4H-Benzo[D][1,3]Dioxin-8-Yl)Methyl)-3- (Hydroxyimino)-4-Phenylindolin-2-One, PDB code: 3g9n
was solved by
M.D.Jacobs,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the JNK3 Bound to (Z)-1-((6-Fluoro-4H-Benzo[D][1,3]Dioxin-8-Yl)Methyl)-3- (Hydroxyimino)-4-Phenylindolin-2-One
(pdb code 3g9n). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the JNK3 Bound to (Z)-1-((6-Fluoro-4H-Benzo[D][1,3]Dioxin-8-Yl)Methyl)-3- (Hydroxyimino)-4-Phenylindolin-2-One, PDB code: 3g9n: Fluorine binding site 1 out of 1 in 3g9nGo back to Fluorine Binding Sites List in 3g9n
Fluorine binding site 1 out
of 1 in the JNK3 Bound to (Z)-1-((6-Fluoro-4H-Benzo[D][1,3]Dioxin-8-Yl)Methyl)-3- (Hydroxyimino)-4-Phenylindolin-2-One
Mono view Stereo pair view
Reference:
J.Cao,
H.Gao,
G.Bemis,
F.Salituro,
M.Ledeboer,
E.Harrington,
S.Wilke,
P.Taslimi,
S.Pazhanisamy,
X.Xie,
M.Jacobs,
J.Green.
Structure-Based Design and Parallel Synthesis of N-Benzyl Isatin Oximes As JNK3 Map Kinase Inhibitors. Bioorg.Med.Chem.Lett. V. 19 2891 2009.
Page generated: Sun Dec 13 11:46:44 2020
ISSN: ISSN 0960-894X PubMed: 19361991 DOI: 10.1016/J.BMCL.2009.03.043 |
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