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Atomistry » Fluorine » PDB 3g72-3gwv » 3gfe » |
Fluorine in PDB 3gfe: Crystal Structure of P38A Mitogen-Activated Protein Kinase in Complex with A Pyrazolopyridinone InhibitorEnzymatic activity of Crystal Structure of P38A Mitogen-Activated Protein Kinase in Complex with A Pyrazolopyridinone Inhibitor
All present enzymatic activity of Crystal Structure of P38A Mitogen-Activated Protein Kinase in Complex with A Pyrazolopyridinone Inhibitor:
2.7.11.24; Protein crystallography data
The structure of Crystal Structure of P38A Mitogen-Activated Protein Kinase in Complex with A Pyrazolopyridinone Inhibitor, PDB code: 3gfe
was solved by
C.Mohr,
S.Jordan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of P38A Mitogen-Activated Protein Kinase in Complex with A Pyrazolopyridinone Inhibitor
(pdb code 3gfe). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of P38A Mitogen-Activated Protein Kinase in Complex with A Pyrazolopyridinone Inhibitor, PDB code: 3gfe: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 3gfeGo back to Fluorine Binding Sites List in 3gfe
Fluorine binding site 1 out
of 2 in the Crystal Structure of P38A Mitogen-Activated Protein Kinase in Complex with A Pyrazolopyridinone Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 3gfeGo back to Fluorine Binding Sites List in 3gfe
Fluorine binding site 2 out
of 2 in the Crystal Structure of P38A Mitogen-Activated Protein Kinase in Complex with A Pyrazolopyridinone Inhibitor
Mono view Stereo pair view
Reference:
R.P.Wurz,
L.H.Pettus,
S.Xu,
B.Henkle,
L.Sherman,
M.Plant,
K.Miner,
H.Mcbride,
L.M.Wong,
C.J.Saris,
M.R.Lee,
S.Chmait,
C.Mohr,
F.Hsieh,
A.S.Tasker.
Part 1: Structure-Activity Relationship (Sar) Investigations of Fused Pyrazoles As Potent, Selective and Orally Available Inhibitors of P38ALPHA Mitogen-Activated Protein Kinase. Bioorg.Med.Chem.Lett. V. 19 4724 2009.
Page generated: Wed Jul 31 18:52:25 2024
ISSN: ISSN 0960-894X PubMed: 19574047 DOI: 10.1016/J.BMCL.2009.06.058 |
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