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Atomistry » Fluorine » PDB 3g72-3gwv » 3gnw » |
Fluorine in PDB 3gnw: Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 4CEnzymatic activity of Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 4C
All present enzymatic activity of Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 4C:
2.7.7.48; Protein crystallography data
The structure of Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 4C, PDB code: 3gnw
was solved by
O.Nyanguile,
H.De Bondt,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3gnw:
The structure of Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 4C also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 4C
(pdb code 3gnw). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 4C, PDB code: 3gnw: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 3gnwGo back to Fluorine Binding Sites List in 3gnw
Fluorine binding site 1 out
of 2 in the Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 4C
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 3gnwGo back to Fluorine Binding Sites List in 3gnw
Fluorine binding site 2 out
of 2 in the Hcv NS5B Polymerase in Complex with 1,5 Benzodiazepine Inhibitor 4C
Mono view Stereo pair view
Reference:
K.Vandyck,
M.D.Cummings,
O.Nyanguile,
C.W.Boutton,
S.Vendeville,
D.Mcgowan,
B.Devogelaere,
K.Amssoms,
S.Last,
K.Rombauts,
A.Tahri,
P.Lory,
L.Hu,
D.A.Beauchamp,
K.Simmen,
P.Raboisson.
Structure-Based Design of A Benzodiazepine Scaffold Yields A Potent Allosteric Inhibitor of Hepatitis C NS5B Rna Polymerase. J.Med.Chem. V. 52 4099 2009.
Page generated: Sun Dec 13 11:47:08 2020
ISSN: ISSN 0022-2623 PubMed: 19507864 DOI: 10.1021/JM9005548 |
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