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Fluorine in PDB 3gpt: Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand
Enzymatic activity of Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand
All present enzymatic activity of Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand:
3.4.25.1;
3.4.25.1;
Protein crystallography data
The structure of Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand, PDB code: 3gpt
was solved by
M.Groll,
V.R.Macherla,
R.R.Manam,
K.A.M.Arthur,
C.B.Potts,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 15.00 / 2.41 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 134.000, 301.260, 143.810, 90.00, 112.56, 90.00 |
| R / Rfree (%) | 22.6 / 24.5 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand
(pdb code 3gpt). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand, PDB code: 3gpt:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand, PDB code: 3gpt:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 3gpt
Go back to
Fluorine Binding Sites List in 3gpt
Fluorine binding site 1 out
of 6 in the Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 3gpt
Go back to
Fluorine Binding Sites List in 3gpt
Fluorine binding site 2 out
of 6 in the Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 3gpt
Go back to
Fluorine Binding Sites List in 3gpt
Fluorine binding site 3 out
of 6 in the Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 3gpt
Go back to
Fluorine Binding Sites List in 3gpt
Fluorine binding site 4 out
of 6 in the Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 3gpt
Go back to
Fluorine Binding Sites List in 3gpt
Fluorine binding site 5 out
of 6 in the Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 3gpt
Go back to
Fluorine Binding Sites List in 3gpt
Fluorine binding site 6 out
of 6 in the Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of the Yeast 20S Proteasome in Complex with Salinosporamide Derivatives: Slow Substrate Ligand within 5.0Å range:
|
Reference:
M.Groll,
K.A.Mcarthur,
V.R.Macherla,
R.R.Manam,
B.C.Potts.
Snapshots of the Fluorosalinosporamide/20S Complex Offer Mechanistic Insights For Fine Tuning Proteasome Inhibition J.Med.Chem. V. 52 5420 2009.
ISSN: ISSN 0022-2623
PubMed: 19678642
DOI: 10.1021/JM900559X
Page generated: Wed Jul 31 18:58:13 2024
ISSN: ISSN 0022-2623
PubMed: 19678642
DOI: 10.1021/JM900559X
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