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Fluorine in PDB 3gwc: Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad
Enzymatic activity of Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad
All present enzymatic activity of Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad:
2.1.1.148;
2.1.1.148;
Protein crystallography data
The structure of Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad, PDB code: 3gwc
was solved by
Seattle Structural Genomics Center For Infectious Disease (Ssgcid),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 48.70 / 1.90 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 81.044, 78.447, 168.959, 90.00, 96.80, 90.00 |
| R / Rfree (%) | 18.7 / 22.9 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad
(pdb code 3gwc). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad, PDB code: 3gwc:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Fluorine where determined in the Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad, PDB code: 3gwc:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Fluorine binding site 1 out of 8 in 3gwc
Go back to
Fluorine Binding Sites List in 3gwc
Fluorine binding site 1 out
of 8 in the Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad within 5.0Å range:
|
Fluorine binding site 2 out of 8 in 3gwc
Go back to
Fluorine Binding Sites List in 3gwc
Fluorine binding site 2 out
of 8 in the Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad within 5.0Å range:
|
Fluorine binding site 3 out of 8 in 3gwc
Go back to
Fluorine Binding Sites List in 3gwc
Fluorine binding site 3 out
of 8 in the Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad within 5.0Å range:
|
Fluorine binding site 4 out of 8 in 3gwc
Go back to
Fluorine Binding Sites List in 3gwc
Fluorine binding site 4 out
of 8 in the Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad within 5.0Å range:
|
Fluorine binding site 5 out of 8 in 3gwc
Go back to
Fluorine Binding Sites List in 3gwc
Fluorine binding site 5 out
of 8 in the Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad within 5.0Å range:
|
Fluorine binding site 6 out of 8 in 3gwc
Go back to
Fluorine Binding Sites List in 3gwc
Fluorine binding site 6 out
of 8 in the Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad within 5.0Å range:
|
Fluorine binding site 7 out of 8 in 3gwc
Go back to
Fluorine Binding Sites List in 3gwc
Fluorine binding site 7 out
of 8 in the Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad within 5.0Å range:
|
Fluorine binding site 8 out of 8 in 3gwc
Go back to
Fluorine Binding Sites List in 3gwc
Fluorine binding site 8 out
of 8 in the Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Crystal Structure of Mycobacterium Tuberculosis Thymidylate Synthase X Bound to Fdump and Fad within 5.0Å range:
|
Reference:
L.Baugh,
I.Phan,
D.W.Begley,
M.C.Clifton,
B.Armour,
D.M.Dranow,
B.M.Taylor,
M.M.Muruthi,
J.Abendroth,
J.W.Fairman,
D.Fox,
S.H.Dieterich,
B.L.Staker,
A.S.Gardberg,
R.Choi,
S.N.Hewitt,
A.J.Napuli,
J.Myers,
L.K.Barrett,
Y.Zhang,
M.Ferrell,
E.Mundt,
K.Thompkins,
N.Tran,
S.Lyons-Abbott,
A.Abramov,
A.Sekar,
D.Serbzhinskiy,
D.Lorimer,
G.W.Buchko,
R.Stacy,
L.J.Stewart,
T.E.Edwards,
W.C.Van Voorhis,
P.J.Myler.
Increasing the Structural Coverage of Tuberculosis Drug Targets. Tuberculosis (Edinb) V. 95 142 2015.
ISSN: ISSN 1472-9792
PubMed: 25613812
DOI: 10.1016/J.TUBE.2014.12.003
Page generated: Sun Dec 13 11:47:14 2020
ISSN: ISSN 1472-9792
PubMed: 25613812
DOI: 10.1016/J.TUBE.2014.12.003
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