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Fluorine in PDB 3h0a: Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist
Enzymatic activity of Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist
All present enzymatic activity of Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist:
2.3.1.48;
2.3.1.48;
Protein crystallography data
The structure of Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist, PDB code: 3h0a
was solved by
Z.Wang,
A.Sudom,
N.P.Walker,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 28.46 / 2.10 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 179.258, 53.825, 67.108, 90.00, 107.74, 90.00 |
| R / Rfree (%) | 24.6 / 34.2 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist
(pdb code 3h0a). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist, PDB code: 3h0a:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist, PDB code: 3h0a:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 3h0a
Go back to
Fluorine Binding Sites List in 3h0a
Fluorine binding site 1 out
of 3 in the Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 3h0a
Go back to
Fluorine Binding Sites List in 3h0a
Fluorine binding site 2 out
of 3 in the Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 3h0a
Go back to
Fluorine Binding Sites List in 3h0a
Fluorine binding site 3 out
of 3 in the Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (Pparg) and Retinoic Acid Receptor Alpha (Rxra) in Complex with 9-Cis Retinoic Acid, Co-Activator Peptide, and A Partial Agonist within 5.0Å range:
|
Reference:
R.V.Connors,
Z.Wang,
M.Harrison,
A.Zhang,
M.Wanska,
S.Hiscock,
B.Fox,
M.Dore,
M.Labelle,
A.Sudom,
S.Johnstone,
J.Liu,
N.P.Walker,
A.Chai,
K.Siegler,
Y.Li,
P.Coward.
Identification of A Ppardelta Agonist with Partial Agonistic Activity on Ppargamma. Bioorg.Med.Chem.Lett. V. 19 3550 2009.
ISSN: ISSN 0960-894X
PubMed: 19464171
DOI: 10.1016/J.BMCL.2009.04.151
Page generated: Mon Jul 14 16:42:15 2025
ISSN: ISSN 0960-894X
PubMed: 19464171
DOI: 10.1016/J.BMCL.2009.04.151
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