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Atomistry » Fluorine » PDB 3igu-3jx2 » 3igv » |
Fluorine in PDB 3igv: Crystal Structure of Hcv NS5B Polymerase with A Novel Monocyclic Dihydro-Pyridinone InhibitorEnzymatic activity of Crystal Structure of Hcv NS5B Polymerase with A Novel Monocyclic Dihydro-Pyridinone Inhibitor
All present enzymatic activity of Crystal Structure of Hcv NS5B Polymerase with A Novel Monocyclic Dihydro-Pyridinone Inhibitor:
2.7.7.48; Protein crystallography data
The structure of Crystal Structure of Hcv NS5B Polymerase with A Novel Monocyclic Dihydro-Pyridinone Inhibitor, PDB code: 3igv
was solved by
Q.Zhao,
R.E.Showalter,
Q.Han,
C.R.Kissinger,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Hcv NS5B Polymerase with A Novel Monocyclic Dihydro-Pyridinone Inhibitor
(pdb code 3igv). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Hcv NS5B Polymerase with A Novel Monocyclic Dihydro-Pyridinone Inhibitor, PDB code: 3igv: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 3igvGo back to Fluorine Binding Sites List in 3igv
Fluorine binding site 1 out
of 2 in the Crystal Structure of Hcv NS5B Polymerase with A Novel Monocyclic Dihydro-Pyridinone Inhibitor
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 3igvGo back to Fluorine Binding Sites List in 3igv
Fluorine binding site 2 out
of 2 in the Crystal Structure of Hcv NS5B Polymerase with A Novel Monocyclic Dihydro-Pyridinone Inhibitor
Mono view Stereo pair view
Reference:
D.A.Ellis,
J.K.Blazel,
C.V.Tran,
F.Ruebsam,
D.E.Murphy,
L.S.Li,
J.Zhao,
Y.Zhou,
H.M.Mcguire,
A.X.Xiang,
S.E.Webber,
Q.Zhao,
Q.Han,
C.R.Kissinger,
M.Lardy,
A.Gobbi,
R.E.Showalter,
A.M.Shah,
M.Tsan,
R.A.Patel,
L.A.Lebrun,
R.Kamran,
D.M.Bartkowski,
T.G.Nolan,
D.A.Norris,
M.V.Sergeeva,
L.Kirkovsky.
5,5'- and 6,6'-Dialkyl-5,6-Dihydro-1H-Pyridin-2- Ones As Potent Inhibitors of Hcv NS5B Polymerase. Bioorg.Med.Chem.Lett. V. 19 6047 2009.
Page generated: Wed Jul 31 19:31:54 2024
ISSN: ISSN 0960-894X PubMed: 19796938 DOI: 10.1016/J.BMCL.2009.09.051 |
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