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Fluorine in PDB 3jsf: Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution
Enzymatic activity of Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution
All present enzymatic activity of Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution:
5.3.2.1; 5.3.3.12;
5.3.2.1; 5.3.3.12;
Protein crystallography data
The structure of Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution, PDB code: 3jsf
was solved by
L.Mclean,
Y.Zhang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 23.91 / 1.93 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 67.649, 67.621, 88.584, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.5 / 22.3 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution
(pdb code 3jsf). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution, PDB code: 3jsf:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution, PDB code: 3jsf:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 3jsf
Go back to
Fluorine Binding Sites List in 3jsf
Fluorine binding site 1 out
of 3 in the Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 3jsf
Go back to
Fluorine Binding Sites List in 3jsf
Fluorine binding site 2 out
of 3 in the Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 3jsf
Go back to
Fluorine Binding Sites List in 3jsf
Fluorine binding site 3 out
of 3 in the Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Macrophage Migration Inhibitory Factor (Mif) with Hydroxyquinoline Inhibitor 638 at 1.93A Resolution within 5.0Å range:
|
Reference:
L.R.Mclean,
Y.Zhang,
H.Li,
Z.Li,
U.Lukasczyk,
Y.M.Choi,
Z.Han,
J.Prisco,
J.Fordham,
J.T.Tsay,
S.Reiling,
R.J.Vaz,
Y.Li.
Discovery of Covalent Inhibitors For Mif Tautomerase Via Cocrystal Structures with Phantom Hits From Virtual Screening. Bioorg.Med.Chem.Lett. V. 19 6717 2009.
ISSN: ISSN 0960-894X
PubMed: 19836948
DOI: 10.1016/J.BMCL.2009.09.106
Page generated: Sun Dec 13 11:48:44 2020
ISSN: ISSN 0960-894X
PubMed: 19836948
DOI: 10.1016/J.BMCL.2009.09.106
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