Fluorine »
PDB 3jx3-3kql »
3k1o »
Fluorine in PDB 3k1o: Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole
Enzymatic activity of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole
All present enzymatic activity of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole:
1.14.13.70;
1.14.13.70;
Protein crystallography data
The structure of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole, PDB code: 3k1o
was solved by
G.I.Lepesheva,
T.Y.Hargrove,
S.Anderson,
Z.Wawrzak,
M.R.Waterman,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.17 / 2.89 |
| Space group | P 31 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 63.121, 63.121, 229.302, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 22.8 / 27.6 |
Other elements in 3k1o:
The structure of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole also contains other interesting chemical elements:
| Iron | (Fe) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole
(pdb code 3k1o). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole, PDB code: 3k1o:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole, PDB code: 3k1o:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 3k1o
Go back to
Fluorine Binding Sites List in 3k1o
Fluorine binding site 1 out
of 2 in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 3k1o
Go back to
Fluorine Binding Sites List in 3k1o
Fluorine binding site 2 out
of 2 in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Trypanosoma Cruzi in Complex with A Potential Antichagasic Drug, Posaconazole within 5.0Å range:
|
Reference:
G.I.Lepesheva,
T.Y.Hargrove,
S.Anderson,
Y.Kleshchenko,
V.Furtak,
Z.Wawrzak,
F.Villalta,
M.R.Waterman.
Structural Insights Into Inhibition of Sterol 14{Alpha}-Demethylase in the Human Pathogen Trypanosoma Cruzi. J.Biol.Chem. V. 285 25582 2010.
ISSN: ISSN 0021-9258
PubMed: 20530488
DOI: 10.1074/JBC.M110.133215
Page generated: Wed Jul 31 19:45:10 2024
ISSN: ISSN 0021-9258
PubMed: 20530488
DOI: 10.1074/JBC.M110.133215
Last articles
Zn in 9JYWZn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
