Fluorine in PDB 3kg2: Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775

The structure of Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775, PDB code: 3kg2 was solved by A.I.Sobolevsky, M.P.Rosconi, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.89 / 3.60
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	90.715, 109.848, 161.130, 85.32, 84.75, 78.92
R / Rfree (%)	28.6 / 29.6

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775 (pdb code 3kg2). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775, PDB code: 3kg2:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775 within 5.0Å range: probe atom residue distance (Å) B Occ A:F833 b:0.9 occ:1.00 FAF A:ZK1833 0.0 0.9 1.0 CAZ A:ZK1833 1.4 0.9 1.0 FAG A:ZK1833 2.2 0.9 1.0 FAH A:ZK1833 2.2 0.9 1.0 CAS A:ZK1833 2.4 0.9 1.0 OH A:TYR732 3.1 0.2 1.0 OG1 A:THR707 3.1 0.5 1.0 CAM A:ZK1833 3.2 0.9 1.0 CAR A:ZK1833 3.2 0.9 1.0 CAJ A:ZK1833 3.3 0.9 1.0 NAX A:ZK1833 3.3 0.9 1.0 CB A:GLU705 4.0 0.5 1.0 CB A:MET708 4.1 0.9 1.0 CAK A:ZK1833 4.3 0.9 1.0 CZ A:TYR732 4.3 0.5 1.0 N A:MET708 4.3 0.1 1.0 CB A:THR707 4.4 0.3 1.0 CAI A:ZK1833 4.4 0.9 1.0 CAN A:ZK1833 4.5 0.9 1.0 CAV A:ZK1833 4.5 0.9 1.0 CA A:MET708 4.7 0.2 1.0 OH A:TYR405 4.8 0.4 1.0 CE2 A:TYR405 4.8 0.4 1.0 CE2 A:TYR732 5.0 0.1 1.0 CAW A:ZK1833 5.0 0.9 1.0 CG A:MET708 5.0 0.4 1.0

Fluorine binding site 2 out of 12 in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775 within 5.0Å range: probe atom residue distance (Å) B Occ A:F833 b:0.9 occ:1.00 FAG A:ZK1833 0.0 0.9 1.0 CAZ A:ZK1833 1.4 0.9 1.0 FAH A:ZK1833 2.2 0.9 1.0 FAF A:ZK1833 2.2 0.9 1.0 CAS A:ZK1833 2.4 0.9 1.0 CAJ A:ZK1833 2.7 0.9 1.0 CB A:PRO478 3.5 0.0 1.0 CE2 A:TYR405 3.6 0.4 1.0 OH A:TYR732 3.6 0.2 1.0 CAR A:ZK1833 3.6 0.9 1.0 OH A:TYR450 3.8 0.8 1.0 CG A:PRO478 3.8 0.8 1.0 CG A:GLU402 3.9 0.5 1.0 CAV A:ZK1833 4.1 0.9 1.0 CD2 A:TYR405 4.1 0.6 1.0 CZ A:TYR405 4.2 0.3 1.0 NAX A:ZK1833 4.2 0.9 1.0 CZ A:TYR732 4.2 0.5 1.0 OH A:TYR405 4.3 0.4 1.0 OG1 A:THR707 4.4 0.5 1.0 CE2 A:TYR732 4.7 0.1 1.0 CD A:GLU402 4.7 0.5 1.0 CAM A:ZK1833 4.7 0.9 1.0 CZ A:TYR450 4.7 0.7 1.0 CAI A:ZK1833 4.8 0.9 1.0 O A:PRO478 4.8 0.6 1.0 CB A:GLU402 4.9 0.9 1.0 CE1 A:TYR732 4.9 0.5 1.0 OE1 A:GLU402 5.0 0.4 1.0 CAW A:ZK1833 5.0 0.9 1.0 NAP A:ZK1833 5.0 0.9 1.0 CAN A:ZK1833 5.0 0.9 1.0 CA A:PRO478 5.0 0.0 1.0

Fluorine binding site 3 out of 12 in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775 within 5.0Å range: probe atom residue distance (Å) B Occ A:F833 b:0.9 occ:1.00 FAH A:ZK1833 0.0 0.9 1.0 CAZ A:ZK1833 1.4 0.9 1.0 FAG A:ZK1833 2.2 0.9 1.0 FAF A:ZK1833 2.2 0.9 1.0 CAS A:ZK1833 2.4 0.9 1.0 NAX A:ZK1833 2.6 0.9 1.0 CAR A:ZK1833 2.8 0.9 1.0 CAN A:ZK1833 3.1 0.9 1.0 CAM A:ZK1833 3.2 0.9 1.0 OE1 A:GLU402 3.3 0.4 1.0 CG A:GLU402 3.4 0.5 1.0 CD A:GLU402 3.6 0.5 1.0 CAJ A:ZK1833 3.6 0.9 1.0 OH A:TYR450 3.9 0.8 1.0 CAK A:ZK1833 3.9 0.9 1.0 CAL A:ZK1833 4.0 0.9 1.0 CAI A:ZK1833 4.2 0.9 1.0 SD A:MET708 4.3 0.6 1.0 CB A:MET708 4.3 0.9 1.0 OE2 A:GLU402 4.5 0.8 1.0 OAQ A:ZK1833 4.6 0.9 1.0 CG A:MET708 4.6 0.4 1.0 CAV A:ZK1833 4.8 0.9 1.0 CB A:GLU402 4.8 0.9 1.0 CE2 A:TYR405 4.9 0.4 1.0

Fluorine binding site 4 out of 12 in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775 within 5.0Å range: probe atom residue distance (Å) B Occ B:F833 b:0.1 occ:1.00 FAF B:ZK1833 0.0 0.1 1.0 CAZ B:ZK1833 1.4 0.1 1.0 FAG B:ZK1833 2.2 0.1 1.0 FAH B:ZK1833 2.2 0.1 1.0 CAS B:ZK1833 2.4 0.1 1.0 OG1 B:THR707 3.1 0.5 1.0 OH B:TYR732 3.1 0.7 1.0 CAM B:ZK1833 3.2 0.1 1.0 CAR B:ZK1833 3.2 0.1 1.0 CAJ B:ZK1833 3.3 0.1 1.0 NAX B:ZK1833 3.3 0.1 1.0 CB B:MET708 4.0 0.9 1.0 CB B:GLU705 4.1 0.6 1.0 CAK B:ZK1833 4.3 0.1 1.0 N B:MET708 4.3 0.1 1.0 CZ B:TYR732 4.3 0.2 1.0 CB B:THR707 4.4 0.9 1.0 CAI B:ZK1833 4.4 0.1 1.0 CAN B:ZK1833 4.5 0.1 1.0 CAV B:ZK1833 4.5 0.1 1.0 CA B:MET708 4.7 0.9 1.0 OH B:TYR405 4.8 0.5 1.0 CE2 B:TYR405 4.8 0.1 1.0 CG B:MET708 5.0 1.0 1.0 CE2 B:TYR732 5.0 0.4 1.0 CAW B:ZK1833 5.0 0.1 1.0

Fluorine binding site 5 out of 12 in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775 within 5.0Å range: probe atom residue distance (Å) B Occ B:F833 b:0.1 occ:1.00 FAG B:ZK1833 0.0 0.1 1.0 CAZ B:ZK1833 1.4 0.1 1.0 FAH B:ZK1833 2.2 0.1 1.0 FAF B:ZK1833 2.2 0.1 1.0 CAS B:ZK1833 2.4 0.1 1.0 CAJ B:ZK1833 2.7 0.1 1.0 CB B:PRO478 3.4 0.0 1.0 CE2 B:TYR405 3.5 0.1 1.0 OH B:TYR732 3.6 0.7 1.0 CAR B:ZK1833 3.6 0.1 1.0 CG B:PRO478 3.8 0.7 1.0 OH B:TYR450 3.9 0.1 1.0 CG B:GLU402 4.0 0.4 1.0 CZ B:TYR405 4.1 0.7 1.0 CD2 B:TYR405 4.1 0.6 1.0 CAV B:ZK1833 4.1 0.1 1.0 CZ B:TYR732 4.2 0.2 1.0 OH B:TYR405 4.2 0.5 1.0 NAX B:ZK1833 4.2 0.1 1.0 OG1 B:THR707 4.4 0.5 1.0 CE2 B:TYR732 4.6 0.4 1.0 CAM B:ZK1833 4.7 0.1 1.0 O B:PRO478 4.8 1.0 1.0 CAI B:ZK1833 4.8 0.1 1.0 CZ B:TYR450 4.8 0.8 1.0 CE1 B:TYR732 4.8 0.9 1.0 CD B:GLU402 4.8 0.6 1.0 CB B:GLU402 4.9 0.1 1.0 CA B:PRO478 4.9 0.8 1.0 CAW B:ZK1833 5.0 0.1 1.0 NAP B:ZK1833 5.0 0.1 1.0 CAN B:ZK1833 5.0 0.1 1.0

Fluorine binding site 6 out of 12 in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775 within 5.0Å range: probe atom residue distance (Å) B Occ B:F833 b:0.1 occ:1.00 FAH B:ZK1833 0.0 0.1 1.0 CAZ B:ZK1833 1.4 0.1 1.0 FAG B:ZK1833 2.2 0.1 1.0 FAF B:ZK1833 2.2 0.1 1.0 CAS B:ZK1833 2.4 0.1 1.0 NAX B:ZK1833 2.6 0.1 1.0 CAR B:ZK1833 2.8 0.1 1.0 CAN B:ZK1833 3.1 0.1 1.0 CAM B:ZK1833 3.2 0.1 1.0 OE1 B:GLU402 3.3 0.7 1.0 CG B:GLU402 3.3 0.4 1.0 CD B:GLU402 3.6 0.6 1.0 CAJ B:ZK1833 3.6 0.1 1.0 OH B:TYR450 3.9 0.1 1.0 CAK B:ZK1833 3.9 0.1 1.0 CAL B:ZK1833 4.0 0.1 1.0 CAI B:ZK1833 4.2 0.1 1.0 SD B:MET708 4.3 0.6 1.0 CB B:MET708 4.4 0.9 1.0 OE2 B:GLU402 4.5 0.4 1.0 OAQ B:ZK1833 4.6 0.1 1.0 CG B:MET708 4.6 1.0 1.0 CB B:GLU402 4.7 0.1 1.0 CAV B:ZK1833 4.8 0.1 1.0 CE2 B:TYR405 4.8 0.1 1.0

Fluorine binding site 7 out of 12 in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775 within 5.0Å range: probe atom residue distance (Å) B Occ C:F833 b:0.6 occ:1.00 FAF C:ZK1833 0.0 0.6 1.0 CAZ C:ZK1833 1.4 0.6 1.0 FAG C:ZK1833 2.2 0.6 1.0 FAH C:ZK1833 2.2 0.6 1.0 CAS C:ZK1833 2.4 0.6 1.0 CAM C:ZK1833 3.1 0.6 1.0 CAR C:ZK1833 3.2 0.6 1.0 OH C:TYR732 3.2 0.9 1.0 OG1 C:THR707 3.2 0.4 1.0 CAJ C:ZK1833 3.3 0.6 1.0 NAX C:ZK1833 3.3 0.6 1.0 CB C:MET708 4.1 0.4 1.0 CB C:GLU705 4.1 0.0 1.0 CAK C:ZK1833 4.3 0.6 1.0 CZ C:TYR732 4.3 0.1 1.0 N C:MET708 4.3 0.3 1.0 CAI C:ZK1833 4.4 0.6 1.0 CB C:THR707 4.5 0.4 1.0 CAN C:ZK1833 4.5 0.6 1.0 CAV C:ZK1833 4.5 0.6 1.0 CA C:MET708 4.7 1.0 1.0 CE2 C:TYR405 4.8 0.6 1.0 OH C:TYR405 4.8 0.1 1.0 CG C:MET708 5.0 0.2 1.0 CAW C:ZK1833 5.0 0.6 1.0

Fluorine binding site 8 out of 12 in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775 within 5.0Å range: probe atom residue distance (Å) B Occ C:F833 b:0.6 occ:1.00 FAG C:ZK1833 0.0 0.6 1.0 CAZ C:ZK1833 1.4 0.6 1.0 FAH C:ZK1833 2.2 0.6 1.0 FAF C:ZK1833 2.2 0.6 1.0 CAS C:ZK1833 2.4 0.6 1.0 CAJ C:ZK1833 2.7 0.6 1.0 CB C:PRO478 3.5 0.4 1.0 CE2 C:TYR405 3.6 0.6 1.0 CAR C:ZK1833 3.6 0.6 1.0 OH C:TYR732 3.7 0.9 1.0 OH C:TYR450 3.8 0.0 1.0 CG C:PRO478 3.8 0.1 1.0 CG C:GLU402 3.9 0.0 1.0 CAV C:ZK1833 4.1 0.6 1.0 CD2 C:TYR405 4.1 0.5 1.0 CZ C:TYR405 4.2 0.7 1.0 NAX C:ZK1833 4.2 0.6 1.0 CZ C:TYR732 4.3 0.1 1.0 OH C:TYR405 4.3 0.1 1.0 OG1 C:THR707 4.5 0.4 1.0 CD C:GLU402 4.7 0.1 1.0 CZ C:TYR450 4.7 0.8 1.0 CAM C:ZK1833 4.7 0.6 1.0 CE2 C:TYR732 4.8 0.9 1.0 O C:PRO478 4.8 0.2 1.0 CAI C:ZK1833 4.8 0.6 1.0 CB C:GLU402 4.8 1.0 1.0 CE1 C:TYR732 4.9 0.9 1.0 OE1 C:GLU402 4.9 0.4 1.0 CA C:PRO478 5.0 0.4 1.0 CAW C:ZK1833 5.0 0.6 1.0 NAP C:ZK1833 5.0 0.6 1.0 CAN C:ZK1833 5.0 0.6 1.0

Fluorine binding site 9 out of 12 in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775 within 5.0Å range: probe atom residue distance (Å) B Occ C:F833 b:0.6 occ:1.00 FAH C:ZK1833 0.0 0.6 1.0 CAZ C:ZK1833 1.4 0.6 1.0 FAG C:ZK1833 2.2 0.6 1.0 FAF C:ZK1833 2.2 0.6 1.0 CAS C:ZK1833 2.4 0.6 1.0 NAX C:ZK1833 2.6 0.6 1.0 CAR C:ZK1833 2.8 0.6 1.0 CAN C:ZK1833 3.1 0.6 1.0 CAM C:ZK1833 3.2 0.6 1.0 OE1 C:GLU402 3.3 0.4 1.0 CG C:GLU402 3.4 0.0 1.0 CD C:GLU402 3.5 0.1 1.0 CAJ C:ZK1833 3.6 0.6 1.0 OH C:TYR450 3.9 0.0 1.0 CAK C:ZK1833 3.9 0.6 1.0 CAL C:ZK1833 4.0 0.6 1.0 CAI C:ZK1833 4.2 0.6 1.0 SD C:MET708 4.3 0.5 1.0 CB C:MET708 4.4 0.4 1.0 OE2 C:GLU402 4.5 0.6 1.0 OAQ C:ZK1833 4.5 0.6 1.0 CG C:MET708 4.6 0.2 1.0 CAV C:ZK1833 4.8 0.6 1.0 CB C:GLU402 4.8 1.0 1.0 CE2 C:TYR405 4.9 0.6 1.0 CZ C:TYR450 5.0 0.8 1.0

Fluorine binding site 10 out of 12 in the Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Ampa Subtype Ionotropic Glutamate Receptor in Complex with Competitive Antagonist Zk 200775 within 5.0Å range: probe atom residue distance (Å) B Occ D:F833 b:0.1 occ:1.00 FAF D:ZK1833 0.0 0.1 1.0 CAZ D:ZK1833 1.4 0.1 1.0 FAG D:ZK1833 2.2 0.1 1.0 FAH D:ZK1833 2.2 0.1 1.0 CAS D:ZK1833 2.4 0.1 1.0 OH D:TYR732 3.0 0.4 1.0 CAM D:ZK1833 3.1 0.1 1.0 CAR D:ZK1833 3.2 0.1 1.0 OG1 D:THR707 3.2 0.6 1.0 CAJ D:ZK1833 3.3 0.1 1.0 NAX D:ZK1833 3.3 0.1 1.0 CZ D:TYR732 4.2 0.8 1.0 CB D:GLU705 4.2 0.8 1.0 CB D:MET708 4.3 0.0 1.0 CAK D:ZK1833 4.3 0.1 1.0 CB D:THR707 4.4 0.8 1.0 CAI D:ZK1833 4.4 0.1 1.0 N D:MET708 4.5 0.5 1.0 CAN D:ZK1833 4.5 0.1 1.0 CAV D:ZK1833 4.5 0.1 1.0 CE2 D:TYR405 4.7 0.4 1.0 OH D:TYR405 4.8 0.1 1.0 CE2 D:TYR732 4.8 0.8 1.0 CA D:MET708 4.9 0.9 1.0 CE1 D:TYR732 5.0 0.5 1.0 CAW D:ZK1833 5.0 0.1 1.0

A.I.Sobolevsky, M.P.Rosconi, E.Gouaux. X-Ray Structure, Symmetry and Mechanism of An Ampa-Subtype Glutamate Receptor. Nature V. 462 745 2009.
ISSN: ISSN 0028-0836
PubMed: 19946266
DOI: 10.1038/NATURE08624