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Fluorine in PDB 3ktu: Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna

Enzymatic activity of Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna

All present enzymatic activity of Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna:
4.2.99.18;

Protein crystallography data

The structure of Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna, PDB code: 3ktu was solved by G.L.Verdine, S.M.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.21 / 2.30
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 92.400, 92.400, 212.500, 90.00, 90.00, 120.00
R / Rfree (%) 22.5 / 25.7

Other elements in 3ktu:

The structure of Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna also contains other interesting chemical elements:

Calcium (Ca) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna (pdb code 3ktu). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna, PDB code: 3ktu:

Fluorine binding site 1 out of 1 in 3ktu

Go back to Fluorine Binding Sites List in 3ktu
Fluorine binding site 1 out of 1 in the Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Human 8-Oxoguanine Glycosylase 1 Bound to Fluorninated Oxog-Containing Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F23

b:68.6
occ:1.00
 F2' C:FDG23 0.0 68.6 1.0
C2' C:FDG23 1.4 69.5 1.0
C1' C:FDG23 2.3 67.5 1.0
C3' C:FDG23 2.5 71.7 1.0
O8 C:FDG23 2.5 59.2 1.0
O4' C:FDG23 2.6 69.2 1.0
N9 C:FDG23 2.9 63.5 1.0
C8 C:FDG23 2.9 61.7 1.0
C4' C:FDG23 3.1 72.2 1.0
CB A:SER147 3.3 50.5 1.0
O3' C:FDG23 3.7 74.0 1.0
OG A:SER147 3.7 51.4 1.0
C5' C:FDG23 3.7 72.9 1.0
O A:SER147 4.0 53.8 1.0
C4 C:FDG23 4.1 61.0 1.0
N7 C:FDG23 4.2 59.7 1.0
CD1 A:ILE155 4.2 46.2 1.0
CE A:LYS249 4.3 56.4 1.0
NZ A:LYS249 4.4 58.7 1.0
CA A:SER147 4.4 52.6 1.0
C A:SER147 4.5 54.7 1.0
O5' C:FDG23 4.6 75.7 1.0
C5 C:FDG23 4.8 60.5 1.0
O A:ASN150 4.8 60.1 1.0
P C:DG24 4.9 76.4 1.0
CD2 A:PHE144 4.9 48.5 1.0
CE2 A:PHE144 4.9 48.5 1.0
N3 C:FDG23 5.0 58.1 1.0

Reference:

G.L.Verdine, S.M.Lee. Structural Investigation of HOGG1 Bound to A Fluorinated Oxog Analog To Be Published.
Page generated: Wed Jul 31 20:12:40 2024

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