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Fluorine in PDB 3kwb: Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor
Enzymatic activity of Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor
All present enzymatic activity of Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor:
3.4.22.38;
3.4.22.38;
Protein crystallography data
The structure of Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor, PDB code: 3kwb
was solved by
J.C.M.Uitdehaag,
M.Van Zeeland,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 27.47 / 2.02 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 31.452, 69.338, 90.850, 90.00, 98.83, 90.00 |
| R / Rfree (%) | 19.4 / 26.3 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor
(pdb code 3kwb). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor, PDB code: 3kwb:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor, PDB code: 3kwb:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 3kwb
Go back to
Fluorine Binding Sites List in 3kwb
Fluorine binding site 1 out
of 6 in the Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 3kwb
Go back to
Fluorine Binding Sites List in 3kwb
Fluorine binding site 2 out
of 6 in the Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 3kwb
Go back to
Fluorine Binding Sites List in 3kwb
Fluorine binding site 3 out
of 6 in the Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 3kwb
Go back to
Fluorine Binding Sites List in 3kwb
Fluorine binding site 4 out
of 6 in the Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 3kwb
Go back to
Fluorine Binding Sites List in 3kwb
Fluorine binding site 5 out
of 6 in the Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 3kwb
Go back to
Fluorine Binding Sites List in 3kwb
Fluorine binding site 6 out
of 6 in the Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Structure of Catk Covalently Bound to A Dioxo-Triazine Inhibitor within 5.0Å range:
|
Reference:
Z.Rankovic,
J.Cai,
X.Fradera,
M.Dempster,
A.Mistry,
A.Mitchell,
C.Long,
E.Hamilton,
A.King,
S.Boucharens,
C.Jamieson,
J.Gillespie,
I.Cumming,
J.Uitdehaag,
M.Van Zeeland.
Dioxo-Triazines As A Novel Series of Cathepsin K Inhibitors Bioorg.Med.Chem.Lett. V. 20 1488 2010.
ISSN: ISSN 0960-894X
PubMed: 20153187
DOI: 10.1016/J.BMCL.2010.01.116
Page generated: Sun Dec 13 11:49:52 2020
ISSN: ISSN 0960-894X
PubMed: 20153187
DOI: 10.1016/J.BMCL.2010.01.116
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