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Fluorine in PDB 3l8v: Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor
Enzymatic activity of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor
All present enzymatic activity of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor, PDB code: 3l8v
was solved by
J.Sack,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 45.18 / 2.40 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.800, 47.250, 154.500, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18.5 / 23.7 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor
(pdb code 3l8v). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor, PDB code: 3l8v:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor, PDB code: 3l8v:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 3l8v
Go back to
Fluorine Binding Sites List in 3l8v
Fluorine binding site 1 out
of 3 in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 3l8v
Go back to
Fluorine Binding Sites List in 3l8v
Fluorine binding site 2 out
of 3 in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 3l8v
Go back to
Fluorine Binding Sites List in 3l8v
Fluorine binding site 3 out
of 3 in the Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor C-Met in Complex with A Biarylamine Based Inhibitor within 5.0Å range:
|
Reference:
D.K.Williams,
X.T.Chen,
C.Tarby,
R.Kaltenbach,
Z.W.Cai,
J.S.Tokarski,
Y.An,
J.S.Sack,
B.Wautlet,
J.Gullo-Brown,
B.J.Henley,
R.Jeyaseelan,
K.Kellar,
V.Manne,
G.L.Trainor,
L.J.Lombardo,
J.Fargnoli,
R.M.Borzilleri.
Design, Synthesis and Structure-Activity Relationships of Novel Biarylamine-Based Met Kinase Inhibitors. Bioorg.Med.Chem.Lett. V. 20 2998 2010.
ISSN: ISSN 0960-894X
PubMed: 20382527
DOI: 10.1016/J.BMCL.2010.01.042
Page generated: Wed Jul 31 20:27:54 2024
ISSN: ISSN 0960-894X
PubMed: 20382527
DOI: 10.1016/J.BMCL.2010.01.042
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