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Atomistry » Fluorine » PDB 3l8v-3lxp » 3lhg | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 3l8v-3lxp » 3lhg » |
Fluorine in PDB 3lhg: BACE1 in Complex with the Aminohydantoin Compound 4GEnzymatic activity of BACE1 in Complex with the Aminohydantoin Compound 4G
All present enzymatic activity of BACE1 in Complex with the Aminohydantoin Compound 4G:
3.4.23.46; Protein crystallography data
The structure of BACE1 in Complex with the Aminohydantoin Compound 4G, PDB code: 3lhg
was solved by
A.M.Olland,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the BACE1 in Complex with the Aminohydantoin Compound 4G
(pdb code 3lhg). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the BACE1 in Complex with the Aminohydantoin Compound 4G, PDB code: 3lhg: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 3lhgGo back to Fluorine Binding Sites List in 3lhg
Fluorine binding site 1 out
of 2 in the BACE1 in Complex with the Aminohydantoin Compound 4G
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 3lhgGo back to Fluorine Binding Sites List in 3lhg
Fluorine binding site 2 out
of 2 in the BACE1 in Complex with the Aminohydantoin Compound 4G
Mono view Stereo pair view
Reference:
P.Zhou,
Y.Li,
Y.Fan,
Z.Wang,
R.Chopra,
A.Olland,
Y.Hu,
R.L.Magolda,
M.Pangalos,
P.H.Reinhart,
M.J.Turner,
J.Bard,
M.S.Malamas,
A.J.Robichaud.
Pyridinyl Aminohydantoins As Small Molecule BACE1 Inhibitors. Bioorg.Med.Chem.Lett. V. 20 2326 2010.
Page generated: Sun Dec 13 11:50:20 2020
ISSN: ISSN 0960-894X PubMed: 20202842 DOI: 10.1016/J.BMCL.2010.01.136 |
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