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Fluorine in PDB 3m4h: Human Aldose Reductase Mutant T113V Complexed with IDD388

Enzymatic activity of Human Aldose Reductase Mutant T113V Complexed with IDD388

All present enzymatic activity of Human Aldose Reductase Mutant T113V Complexed with IDD388:
1.1.1.21;

Protein crystallography data

The structure of Human Aldose Reductase Mutant T113V Complexed with IDD388, PDB code: 3m4h was solved by C.Koch, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 0.94
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 49.390, 66.880, 47.370, 90.00, 92.11, 90.00
R / Rfree (%) 10.3 / 12.2

Other elements in 3m4h:

The structure of Human Aldose Reductase Mutant T113V Complexed with IDD388 also contains other interesting chemical elements:

Bromine (Br) 2 atoms
Chlorine (Cl) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Human Aldose Reductase Mutant T113V Complexed with IDD388 (pdb code 3m4h). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Aldose Reductase Mutant T113V Complexed with IDD388, PDB code: 3m4h:

Fluorine binding site 1 out of 1 in 3m4h

Go back to Fluorine Binding Sites List in 3m4h
Fluorine binding site 1 out of 1 in the Human Aldose Reductase Mutant T113V Complexed with IDD388


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Aldose Reductase Mutant T113V Complexed with IDD388 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F600

b:5.7
occ:0.73
F9 A:388600 0.0 5.7 0.7
C7 A:388600 1.3 4.1 0.7
CB A:LEU300 1.6 7.8 0.3
CA A:LEU300 1.8 9.8 0.3
N A:LEU300 2.0 8.5 0.3
C2 A:388600 2.3 3.6 0.7
C6 A:388600 2.4 4.7 0.7
C1 A:388600 2.8 4.2 0.7
C A:ALA299 3.0 9.2 0.3
CA A:ALA299 3.2 6.2 0.7
C A:ALA299 3.2 6.2 0.7
N A:LEU300 3.2 5.2 0.7
CH2 A:TRP111 3.2 6.0 1.0
C A:LEU300 3.3 9.4 0.3
CB A:LEU300 3.5 5.7 0.7
N A:ALA299 3.5 5.9 0.7
C3 A:388600 3.6 3.5 0.7
C5 A:388600 3.6 4.8 0.7
CZ3 A:TRP111 3.6 5.0 1.0
O A:ALA299 3.6 8.9 0.3
CZ2 A:TRP111 3.7 5.8 1.0
O A:ALA299 3.8 7.3 0.7
CA A:ALA299 4.0 9.4 0.3
N A:ALA299 4.0 7.2 0.3
O A:LEU300 4.0 11.6 0.3
CA A:LEU300 4.0 4.7 0.7
C A:CYS298 4.0 5.5 0.7
O A:CYS298 4.1 6.7 0.3
OH A:TYR309 4.1 6.3 0.7
C4 A:388600 4.1 4.3 0.7
C A:CYS298 4.1 4.7 0.3
O A:CYS298 4.2 5.9 0.7
N10 A:388600 4.2 3.5 0.7
CE1 A:TYR309 4.2 5.3 0.7
N A:LEU301 4.2 10.5 0.3
CE3 A:TRP111 4.4 4.0 1.0
CE2 A:TRP111 4.5 4.2 1.0
BR A:BR800 4.5 9.7 0.2
CB A:ALA299 4.6 8.6 0.7
CE2 A:PHE311 4.6 7.0 1.0
CZ A:TYR309 4.6 5.5 0.7
CD2 A:TRP111 4.8 3.4 1.0
CG A:LEU300 4.9 5.7 0.7
SG A:CYS298 4.9 1.9 0.3
CB A:CYS298 4.9 7.7 0.7
CA A:CYS298 4.9 4.8 0.7
O A:LEU300 5.0 5.3 0.7

Reference:

C.Koch, A.Heine, G.Klebe. Tracing the Detail: How Mutations Affect Binding Modes and Thermodynamic Signatures of Closely Related Aldose Reductase Inhibitors J.Mol.Biol. V. 406 700 2011.
ISSN: ISSN 0022-2836
PubMed: 21185307
DOI: 10.1016/J.JMB.2010.11.058
Page generated: Sun Dec 13 11:50:51 2020

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