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Atomistry » Fluorine » PDB 3nlz-3og7 » 3o28 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 3nlz-3og7 » 3o28 » |
Fluorine in PDB 3o28: Ligand-Binding Domain of GLUA2 (Flip) Ionotropic Glutamate Receptor in Complex with An Allosteric ModulatorProtein crystallography data
The structure of Ligand-Binding Domain of GLUA2 (Flip) Ionotropic Glutamate Receptor in Complex with An Allosteric Modulator, PDB code: 3o28
was solved by
J.K.F.Maclean,
S.Basten,
R.A.Campbell,
I.A.Cumming,
K.J.Gillen,
J.Gillespie,
C.Jamieson,
B.Kazemier,
M.Kiczun,
Y.Lamont,
A.J.Lyons,
E.M.Moir,
J.A.Morrow,
M.Papakosta,
Z.Rankovic,
L.Smith,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Ligand-Binding Domain of GLUA2 (Flip) Ionotropic Glutamate Receptor in Complex with An Allosteric Modulator
(pdb code 3o28). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Ligand-Binding Domain of GLUA2 (Flip) Ionotropic Glutamate Receptor in Complex with An Allosteric Modulator, PDB code: 3o28: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 3o28Go back to![]() ![]()
Fluorine binding site 1 out
of 3 in the Ligand-Binding Domain of GLUA2 (Flip) Ionotropic Glutamate Receptor in Complex with An Allosteric Modulator
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 3 in 3o28Go back to![]() ![]()
Fluorine binding site 2 out
of 3 in the Ligand-Binding Domain of GLUA2 (Flip) Ionotropic Glutamate Receptor in Complex with An Allosteric Modulator
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 3 in 3o28Go back to![]() ![]()
Fluorine binding site 3 out
of 3 in the Ligand-Binding Domain of GLUA2 (Flip) Ionotropic Glutamate Receptor in Complex with An Allosteric Modulator
![]() Mono view ![]() Stereo pair view
Reference:
C.Jamieson,
S.Basten,
R.A.Campbell,
I.A.Cumming,
K.J.Gillen,
J.Gillespie,
B.Kazemier,
M.Kiczun,
Y.Lamont,
A.J.Lyons,
J.K.Maclean,
E.M.Moir,
J.A.Morrow,
M.Papakosta,
Z.Rankovic,
L.Smith.
A Novel Series of Positive Modulators of the Ampa Receptor: Discovery and Structure Based Hit-to-Lead Studies. Bioorg.Med.Chem.Lett. V. 20 5753 2010.
Page generated: Wed Jul 31 21:08:46 2024
ISSN: ISSN 0960-894X PubMed: 20805031 DOI: 10.1016/J.BMCL.2010.07.138 |
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