Fluorine in PDB 3ozl: Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid.

The structure of Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid., PDB code: 3ozl was solved by L.M.T.R.Lima, L.C.Palmieri, D.Foguel, F.L.Palhano, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.14 / 1.90
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	43.930, 85.607, 65.228, 90.00, 90.00, 90.00
R / Rfree (%)	19.9 / 24.7

The binding sites of Fluorine atom in the Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid. (pdb code 3ozl). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid., PDB code: 3ozl:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid. within 5.0Å range: probe atom residue distance (Å) B Occ A:F501 b:43.1 occ:0.50 F1 A:FLF501 0.0 43.1 0.5 C7' A:FLF501 1.3 42.8 0.5 F3 A:FLF501 2.1 43.2 0.5 F2 A:FLF501 2.1 41.9 0.5 C3' A:FLF501 2.3 42.5 0.5 C4' A:FLF501 3.2 42.7 0.5 C2' A:FLF501 3.3 42.8 0.5 CD2 A:LEU110 3.5 16.7 1.0 C5' A:FLF501 4.4 42.3 0.5 CG A:LEU110 4.6 16.0 1.0 CD1 A:LEU110 4.6 15.8 1.0 C1' A:FLF501 4.7 43.0 0.5 O A:HOH206 4.8 37.3 0.5

Fluorine binding site 2 out of 6 in the Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid. within 5.0Å range: probe atom residue distance (Å) B Occ A:F501 b:41.9 occ:0.50 F2 A:FLF501 0.0 41.9 0.5 C7' A:FLF501 1.3 42.8 0.5 F3 A:FLF501 2.1 43.2 0.5 F1 A:FLF501 2.1 43.1 0.5 C3' A:FLF501 2.3 42.5 0.5 C2' A:FLF501 2.9 42.8 0.5 C4' A:FLF501 3.5 42.7 0.5 C1' A:FLF501 4.4 43.0 0.5 C5' A:FLF501 4.7 42.3 0.5

Fluorine binding site 3 out of 6 in the Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid. within 5.0Å range: probe atom residue distance (Å) B Occ A:F501 b:43.2 occ:0.50 F3 A:FLF501 0.0 43.2 0.5 C7' A:FLF501 1.3 42.8 0.5 F2 A:FLF501 2.1 41.9 0.5 F1 A:FLF501 2.1 43.1 0.5 C3' A:FLF501 2.4 42.5 0.5 C4' A:FLF501 2.7 42.7 0.5 O A:HOH206 3.2 37.3 0.5 C2' A:FLF501 3.7 42.8 0.5 CD2 A:LEU110 4.0 16.7 1.0 C5' A:FLF501 4.1 42.3 0.5 OG A:SER117 4.9 19.6 0.5 C1' A:FLF501 5.0 43.0 0.5

Fluorine binding site 4 out of 6 in the Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid. within 5.0Å range: probe atom residue distance (Å) B Occ B:F502 b:37.6 occ:0.50 F1 B:FLF502 0.0 37.6 0.5 C7' B:FLF502 1.3 38.6 0.5 F2 B:FLF502 2.1 38.2 0.5 F3 B:FLF502 2.2 38.4 0.5 C3' B:FLF502 2.3 38.8 0.5 C2' B:FLF502 3.1 39.1 0.5 C4' B:FLF502 3.2 38.8 0.5 CD2 B:LEU110 3.7 15.8 1.0 C1' B:FLF502 4.4 39.0 0.5 C5' B:FLF502 4.4 39.1 0.5 CG B:LEU110 4.7 14.2 1.0 CD1 B:LEU110 4.8 14.7 1.0 O B:HOH153 4.8 28.1 0.5 C6' B:FLF502 4.9 39.0 0.5

Fluorine binding site 5 out of 6 in the Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid. within 5.0Å range: probe atom residue distance (Å) B Occ B:F502 b:38.2 occ:0.50 F2 B:FLF502 0.0 38.2 0.5 C7' B:FLF502 1.3 38.6 0.5 F1 B:FLF502 2.1 37.6 0.5 F3 B:FLF502 2.2 38.4 0.5 C3' B:FLF502 2.3 38.8 0.5 C2' B:FLF502 2.7 39.1 0.5 C4' B:FLF502 3.6 38.8 0.5 C1' B:FLF502 4.1 39.0 0.5 C5' B:FLF502 4.7 39.1 0.5 C6' B:FLF502 4.9 39.0 0.5 N B:FLF502 4.9 38.8 0.5

Fluorine binding site 6 out of 6 in the Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid. within 5.0Å range: probe atom residue distance (Å) B Occ B:F502 b:38.4 occ:0.50 F3 B:FLF502 0.0 38.4 0.5 C7' B:FLF502 1.3 38.6 0.5 F1 B:FLF502 2.2 37.6 0.5 F2 B:FLF502 2.2 38.2 0.5 C3' B:FLF502 2.3 38.8 0.5 C4' B:FLF502 2.7 38.8 0.5 O B:HOH153 3.2 28.1 0.5 C2' B:FLF502 3.6 39.1 0.5 C5' B:FLF502 4.1 39.1 0.5 CD2 B:LEU110 4.1 15.8 1.0 C1' B:FLF502 4.7 39.0 0.5 OG B:SER117 4.8 18.6 0.5 C6' B:FLF502 4.9 39.0 0.5

L.M.T.R.Lima, L.C.Palmieri, D.Foguel, F.L.Palhano. Crystal Structure of Human Transthyretin Variant A25T in Complex with Flufenamic Acid. To Be Published.