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Atomistry » Fluorine » PDB 3oyl-3pr2 » 3pj2 » |
Fluorine in PDB 3pj2: Crystal Structure of Btk Kinase Domain Complexed with 2-[4-(2- Diethylamino-Ethoxy)-Phenylamino]-6-(4-Fluoro-Phenoxy)-8-Methyl-8H- Pyrido[2,3-D]Pyrimidin-7-OneEnzymatic activity of Crystal Structure of Btk Kinase Domain Complexed with 2-[4-(2- Diethylamino-Ethoxy)-Phenylamino]-6-(4-Fluoro-Phenoxy)-8-Methyl-8H- Pyrido[2,3-D]Pyrimidin-7-One
All present enzymatic activity of Crystal Structure of Btk Kinase Domain Complexed with 2-[4-(2- Diethylamino-Ethoxy)-Phenylamino]-6-(4-Fluoro-Phenoxy)-8-Methyl-8H- Pyrido[2,3-D]Pyrimidin-7-One:
2.7.10.2; Protein crystallography data
The structure of Crystal Structure of Btk Kinase Domain Complexed with 2-[4-(2- Diethylamino-Ethoxy)-Phenylamino]-6-(4-Fluoro-Phenoxy)-8-Methyl-8H- Pyrido[2,3-D]Pyrimidin-7-One, PDB code: 3pj2
was solved by
A.Kuglstatter,
A.Wong,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Btk Kinase Domain Complexed with 2-[4-(2- Diethylamino-Ethoxy)-Phenylamino]-6-(4-Fluoro-Phenoxy)-8-Methyl-8H- Pyrido[2,3-D]Pyrimidin-7-One
(pdb code 3pj2). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Btk Kinase Domain Complexed with 2-[4-(2- Diethylamino-Ethoxy)-Phenylamino]-6-(4-Fluoro-Phenoxy)-8-Methyl-8H- Pyrido[2,3-D]Pyrimidin-7-One, PDB code: 3pj2: Fluorine binding site 1 out of 1 in 3pj2Go back to Fluorine Binding Sites List in 3pj2
Fluorine binding site 1 out
of 1 in the Crystal Structure of Btk Kinase Domain Complexed with 2-[4-(2- Diethylamino-Ethoxy)-Phenylamino]-6-(4-Fluoro-Phenoxy)-8-Methyl-8H- Pyrido[2,3-D]Pyrimidin-7-One
Mono view Stereo pair view
Reference:
A.Kuglstatter,
A.Wong,
S.Tsing,
S.W.Lee,
Y.Lou,
A.G.Villasenor,
J.M.Bradshaw,
D.Shaw,
J.W.Barnett,
M.F.Browner.
Insights Into the Conformational Flexibility of Bruton'S Tyrosine Kinase From Multiple Ligand Complex Structures. Protein Sci. V. 20 428 2011.
Page generated: Sun Dec 13 11:53:12 2020
ISSN: ISSN 0961-8368 PubMed: 21280133 DOI: 10.1002/PRO.575 |
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