Fluorine »
PDB 3oyl-3pr2 »
3pjc »
Fluorine in PDB 3pjc: Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
Enzymatic activity of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
All present enzymatic activity of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family:
2.7.10.2;
2.7.10.2;
Protein crystallography data
The structure of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family, PDB code: 3pjc
was solved by
G.A.Tavares,
G.Thoma,
H.-G.Zerwes,
M.Kroemer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 59.87 / 2.20 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 41.722, 71.991, 107.800, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18 / 21.5 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
(pdb code 3pjc). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family, PDB code: 3pjc:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family, PDB code: 3pjc:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 3pjc
Go back to
Fluorine Binding Sites List in 3pjc
Fluorine binding site 1 out
of 3 in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 3pjc
Go back to
Fluorine Binding Sites List in 3pjc
Fluorine binding site 2 out
of 3 in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 3pjc
Go back to
Fluorine Binding Sites List in 3pjc
Fluorine binding site 3 out
of 3 in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family within 5.0Å range:
|
Reference:
G.Thoma,
F.Nuninger,
R.Falchetto,
E.Hermes,
G.A.Tavares,
E.Vangrevelinghe,
H.G.Zerwes.
Identification of A Potent Janus Kinase 3 Inhibitor with High Selectivity Within the Janus Kinase Family. J.Med.Chem. V. 54 284 2011.
ISSN: ISSN 0022-2623
PubMed: 21155605
DOI: 10.1021/JM101157Q
Page generated: Wed Jul 31 21:43:02 2024
ISSN: ISSN 0022-2623
PubMed: 21155605
DOI: 10.1021/JM101157Q
Last articles
Zn in 9J0NZn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
