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Fluorine in PDB 3pjc: Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
Enzymatic activity of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
All present enzymatic activity of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family:
2.7.10.2;
2.7.10.2;
Protein crystallography data
The structure of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family, PDB code: 3pjc
was solved by
G.A.Tavares,
G.Thoma,
H.-G.Zerwes,
M.Kroemer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 59.87 / 2.20 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 41.722, 71.991, 107.800, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18 / 21.5 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
(pdb code 3pjc). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family, PDB code: 3pjc:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family, PDB code: 3pjc:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 3pjc
Go back to
Fluorine Binding Sites List in 3pjc
Fluorine binding site 1 out
of 3 in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 3pjc
Go back to
Fluorine Binding Sites List in 3pjc
Fluorine binding site 2 out
of 3 in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 3pjc
Go back to
Fluorine Binding Sites List in 3pjc
Fluorine binding site 3 out
of 3 in the Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of JAK3 Complexed with A Potent Atp Site Inhibitor Showing High Selectivity Within the Janus Kinase Family within 5.0Å range:
|
Reference:
G.Thoma,
F.Nuninger,
R.Falchetto,
E.Hermes,
G.A.Tavares,
E.Vangrevelinghe,
H.G.Zerwes.
Identification of A Potent Janus Kinase 3 Inhibitor with High Selectivity Within the Janus Kinase Family. J.Med.Chem. V. 54 284 2011.
ISSN: ISSN 0022-2623
PubMed: 21155605
DOI: 10.1021/JM101157Q
Page generated: Sun Dec 13 11:53:12 2020
ISSN: ISSN 0022-2623
PubMed: 21155605
DOI: 10.1021/JM101157Q
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